1-Boc-2-methylpiperidine

Base Information

Chemical Name:1-Boc-2-methylpiperidine
CAS No.:126503-04-6
Molecular Formula:C11H21NO2
Molecular Weight:199.293
Hs Code.:
DSSTox Substance ID:DTXSID40404467
Nikkaji Number:J2.006.316E

Synonyms:1-Boc-2-methylpiperidine;126503-04-6;tert-butyl 2-methylpiperidine-1-carboxylate;N-Boc-2-Methyl-Piperidine;rac 1-Boc-2-methyl-piperidine;MFCD02093759;1-Boc-2-methyl-piperidine;SCHEMBL1202111;DTXSID40404467;DHJKRRZIUOQEFW-UHFFFAOYSA-N;BFA50304;AKOS009158428;SB41697;CS-0079038;FT-0771542;D74019;2-methylpiperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 1-Boc-2-methylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-Boc-2-methylpiperidine

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:199.157228913
Heavy Atom Count:14
Complexity:208

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCCN1C(=O)OC(C)(C)C

Technology Process of 1-Boc-2-methylpiperidine

There total 1 articles about 1-Boc-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34825-70-2
hex-5-en-1-amine

: 126503-04-6
tert-butyl 2-methylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / Et₃N / CH₂Cl₂

2: 92 percent / 2,6-bis(diphenylphosphinomethyl)pyridine dichloropalladium; AgBF₄; Cu(OTf)2 / 3 Angstroem molecular sieves / CH₂Cl₂

With silver tetrafluoroborate; 2,6-bis(diphenylphosphinomethyl)pyridine dichloropalladium; copper(II) bis(trifluoromethanesulfonate); triethylamine; 3 A molecular sieve; In dichloromethane;
DOI:10.1021/ja060126h

Reference yield: 82.0%

: 455-13-0
4-Iodobenzotrifluoride

: 126503-04-6
tert-butyl 2-methylpiperidine-1-carboxylate

: trans-t-butyl 2-methyl-5-(4-(trifluoromethyl)phenyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 2-methylpiperidine-1-carboxylate; With sec.-butyllithium; Trimethylenediamine; In diethyl ether; hexane; at -78 ℃; for 4h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; for 0.25h; Inert atmosphere;

4-Iodobenzotrifluoride; With bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos; In tetrahydrofuran; hexane; at 0 - 40 ℃; for 36h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja201008e

Reference yield: 39.0%

: 2859-78-1
4-Bromoveratrole

: 126503-04-6
tert-butyl 2-methylpiperidine-1-carboxylate

: tert-butyl 2-(3,4-dimethoxyphenyl)-6-methylpiperidine-1-carboxylate

Guidance literature:: tert-butyl 2-methylpiperidine-1-carboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; at -78 ℃; for 3h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

4-Bromoveratrole; With tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 18h;
DOI:10.1021/ol801579r