4-METHYLPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 4-METHYLPHENYLGLYOXAL HYDRATE
• CAS No.: 16208-14-3
• Molecular Formula: C9H8O2
• Molecular Weight: 166.177
• Hs Code.: 2915900090
• Mol file: 16208-14-3.mol

Synonyms:4-Methylphenylglyoxal hydrate;2,2-dihydroxy-1-(4-methylphenyl)ethanone;

Chemical Property of 4-METHYLPHENYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 0.0503mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 235.3 °C at 760 mmHg
• PKA: 10.66±0.41(Predicted)
• Flash Point: 87.3 °C
• PSA: 43.37000
• Density: 1.101 g/cm³
• LogP: 1.31230

Purity/Quality:

98%min ^*data from raw suppliers

4-Methylphenylglyoxal hydrate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLPHENYLGLYOXAL HYDRATE

There total 4 articles about 4-METHYLPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

para-methylacetophenone (122-00-9) → 2,2-dihydroxy-1-(p-tolyl)ethanone (16208-14-3)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/co4000198

Reference yield: 75.0%

4-methylphenylglyoxal (1075-47-4) → 2,2-dihydroxy-1-(p-tolyl)ethanone (16208-14-3)

Guidance literature:

With water; Heating;

Reference yield:

p-tolylglyoxalmonoxime (17628-76-1,1089298-03-2) → 2,2-dihydroxy-1-(p-tolyl)ethanone (16208-14-3)

Guidance literature:

With sodium disulfite; Kochen des erhaltenen Produkts mit verd. Schwefelsaeure;

upstream raw materials:

p-tolylglyoxalmonoxime

4-methylphenylglyoxal

para-methylacetophenone

Downstream raw materials:

(S)-(-)-2-hydroxy-3-nitro-2-p-tolylpropanal

C₂₁H₂₀N₄O₂

C₂₁H₁₉ClN₄O₂

4-methylphenylglyoxal

Refernces

• 1、 Poursattar Marjani, Ahmad,Khalafy, Jabbar,Farajollahi, Ayda. "Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB". . p. 268 - 274. Retrieved 2018/11/30.
• 2、 Khalafy, Jabbar,Etivand, Nasser,Poursattar Marjani, Ahmad,Khalillou, Neda. "Synthesis of 4-Hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the Presence of DABCO as an Efficient Organocatalyst". . p. 1857 - 1865. Retrieved 2019/05/21.