1075-47-4

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYLPHENYLGLYOXAL HYDRATE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its ability to participate in multiple chemical reactions makes it a valuable component in the development of new drugs and medicinal compounds.
Used in Dye Industry:
In the dye industry, 4-METHYLPHENYLGLYOXAL HYDRATE is utilized as a precursor in the production of dyes. Its chemical properties allow for the creation of a wide range of colorants used in textiles, plastics, and other materials.
Used in Polymer and Resin Production:
4-METHYLPHENYLGLYOXAL HYDRATE is employed as a key component in the manufacturing of high-performance polymers and resins. Its involvement in the synthesis process contributes to the development of materials with enhanced properties for use in various applications.
Used as an Antimicrobial Agent:
Recognized for its potential as an antimicrobial agent, 4-METHYLPHENYLGLYOXAL HYDRATE is used in applications where the control of microbial growth is necessary, such as in medical devices, water treatment, and food preservation.
Used in Organic Synthesis:
4-METHYLPHENYLGLYOXAL HYDRATE is also utilized in organic synthesis for the preparation of various organic compounds. Its reactivity in different types of chemical reactions makes it a useful building block in the synthesis of complex organic molecules.

InChI:InChI=1/C9H8O2.H2O/c1-7-2-4-8(5-3-7)9(11)6-10;/h2-6H,1H3;1H2

Upstream product

• 4974-59-8 2,2-dichloro-4'-methylacetophenone 
• 79-36-7 dichloroacethyl chloride 
• 108-88-3 toluene 
• 4209-24-9 p-methylphenacyl chloride 
• 139016-20-9 (S)-1-(4-methylphenyl)-1,2-ethanediol 
• 619-41-0 4-(bromoacetyl)toluene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 4079-54-3 2-hydroxy-1-p-tolyl-ethanone 
• 40805-62-7 2-iodo-1-(4-methylphenyl)ethanone 
• 16208-14-3 2,2-dihydroxy-1-(p-tolyl)ethanone 
• 1855-08-9 1-(p-Tolyl)-1,2-propanedione 

Downstream Products

• 861366-07-6 p-tolyl-glyoxylohydroximic acid 
• 18584-20-8 (R)-para-methylmandelic acid 
• 17565-28-5 p-tolyl-glyoxal-bis-phenylhydrazone 
• 2431-23-4 4-methylbenzoin 
• 54149-87-0 2-hydroxy-2-morpholin-4-yl-1-p-tolyl-ethanone 
• 25561-39-1 2-morpholin-4-ylimino-1-p-tolyl-ethanone 
• 16019-01-5 [3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3a-methyl-hexahydro-furo[2,3-d]thiazol-2-yl]-p-tolyl-methanone 
• 16019-02-6 [9-(2-hydroxy-ethyl)-2,9a-dimethyl-5,9,9a,10-tetrahydro-pyrimido[4,5-d]thiazolo[3,4-a]pyrimidin-7-yl]-p-tolyl-methanone 
• 123488-72-2 2-Hydroxy-2-(pyridin-2-ylamino)-1-p-tolyl-ethanone 
• 123488-75-5 2-Hydroxy-2-(5-methyl-pyridin-2-ylamino)-1-p-tolyl-ethanone 
• 140613-77-0 3-methyl-2-p-toluoyloxazolidine 
• 118673-91-9 (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1-hydroxy-2-oxo-2-p-tolyl-ethylsulfanyl)-ethylcarbamoyl]-butyric acid 
• 83256-66-0 C₂₅H₂₄N₄O₂ 
• 105592-60-7 2-[Methyl-(2-phenyl-[1,3]dioxolan-2-ylmethyl)-hydrazono]-1-p-tolyl-ethanone 

Relevant academic research and scientific papers

Copper-Catalyzed Enantioselective Hetero-Diels-Alder Reaction of Danishefsky's Diene with Glyoxals

(Chemical Equation Presented) The highly enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with glyoxals was developed by virtue of a readily accessible chiral copper catalyst. This efficient transformation provided a facile and scalable

Reactions of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates and 1-aryl-2-ene-3-acetyl-1,4-diketones: One-pot synthesis of highly functionalized 5-cyclohexylimino-2,5-dihydrofurans

Dihydrofurans are important intermediates in organic synthesis, and are also important starting materials used in syntheses of a number of natural products. A facile synthesis of highly functionalized 5- cyclohexylimino-2,5-dihydrofuran derivatives by the multi-component reaction of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates and 1-aryl-2-ene-3-acetyl-1,4-diketones is described.

A 2 - cyano - 4 - chloro - 5 - (4 - methyl phenyl) imidazole synthesis method

The invention relates to a synthetic method for 2-cyano-4-chloro-5-(4-methylphenyl)imidazole. The synthetic method comprises the following steps: (1) by taking p-methylacetophenone as a raw material, carrying out a halogenating reaction under a light condition to obtain a compound I; (2) dissolving the obtained compound I in a solvent, stirring the mixture to react at a certain temperature, and performing cooling and suction-filtering to obtain a compound II; (3) dissolving the obtained compound II in a solvent and carrying out a reaction with glyoxal and hydroxylamine sulphate at a certain temperature to obtain a compound III; and (4) dissolving the obtained compound III in a solvent, carrying out a reaction with sulfoxide chloride in an ice bath in a manner of raising the temperature to room temperature and keeping the temperature for the reaction, dropwise adding sulfur chloride, and after reaction, washing the product to obtain a compound IV which is 2-cyano-4-chloro-5-(4-methylphenyl)imidazole. The synthetic method is good in atom economy, simple and convenient in process operation and high in product yield and industrial application value.

Metal free one-pot synthesis of α-ketoamides from terminal alkenes

A practical approach towards the synthesis of α-ketoamides from readily available terminal alkenes (styrenes) has been developed. Use of inexpensive I2/2-iodoxybenzoic acid (IBX) in dimethyl sulphoxide (DMSO) as an oxidant under metal free one-pot conditions makes this methodology versatile.

Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.

PYRIDOPYRAZINES AS ANTICANCER AGENTS

The present invention relates to pyridopyrazine derivatives and solvates, hydrates and pharmaceutically acceptable salts thereof, the use of them in the prevention and/or the treatment of cancer diseases, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of cancer diseases.˙

Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones

An I2/KOH synergistically promoted direct ring-opening aroylation of benzothiazoles with aryl ketones has been discovered. Aryl ketones were seen to act as carbonyl sources to construct 2-acylbenzothiazoles. This reaction could provide an example for the convergent integration of self-labor domino sequences based on an in situ cross-trapping strategy.

Synthesis of trisubstituted isoxazoles via in situ trapping strategy from α-nitro carbonyl compounds and methyl ketones or terminal aryl alkenes

A highly efficient domino method for the synthesis of trisubstituted isoxazoles has been established from α-nitro carbonyl compounds and methyl ketones or terminal aryl alkenes. Simple and readily available starting materials, mild reaction conditions and very simple operation are significant advantages of the reaction.

A multipathway coupled domino strategy: Metal-free oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles from multiform substrates

A multipathway coupled domino strategy has been developed for the efficient synthesis of 2-acylbenzothiazoles from multiform substrates arylethenes, arylacetylenes, 2-hydroxy-aromatic ketones, and carbinols via four distinct pathways. Through a logical coupled oxidation/heterocyclization domino process, a variety of 2-acylbenzothiazoles were synthesized free of metal in one pot.

Selective oxidation of benzylic or allylic hydroxyl group of sec-1,2-diols

A mild and efficient method to selectively oxidize chiral sec-1,2-diols has been developed, which demonstrates that 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ) can selectively oxidize benzylic or allylic hydroxyl group of sec-1,2-diols under ultrasound wave promotion. The configuration of the adjacent chiral center is retained.