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(R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin

Base Information Edit
  • Chemical Name:(R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin
  • CAS No.:127126-18-5
  • Molecular Formula:C16H24FNO
  • Molecular Weight:265.36600
  • Hs Code.:
  • UNII:44B1597K8X
  • DSSTox Substance ID:DTXSID901169818
  • Nikkaji Number:J322.181D
  • Wikidata:Q27088648
  • Pharos Ligand ID:SSHH3QJXPU53
  • ChEMBL ID:CHEMBL41716
  • Mol file:127126-18-5.mol
(R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin

Synonyms:127126-18-5;(R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin;UH-301 free base, (R)-;UNII-44B1597K8X;1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, (7R)-;44B1597K8X;CHEMBL41716;(R)-(+)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin;(7R)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydronaphthalen-1-ol;(R)-UH 301;(R)-7-(Dipropylamino)-4-fluoro-5,6,7,8-tetrahydronaphthalen-1-ol;(R)-UH-301;D06ROA;(R)-uh-301 free base;Lopac0_001246;7-Dipropylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol;GTPL3218;SCHEMBL7749343;DTXSID901169818;BDBM50013020;CCG-205320;NCGC00162377-01;(+)-UH 301;5-fluoro-8-hydroxy-2-(dipropylamino) tetralin;Q27088648;(R)-7-Dipropylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol;(7R)-7-(Dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-1-naphthalenol

Suppliers and Price of (R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • R(+)-UH-301
  • 1mg
  • $ 205.00
  • TRC
  • R(+)-UH-301
  • 2.5mg
  • $ 410.00
  • Sigma-Aldrich
  • R(+)-UH-301 hydrochloride solid
  • 1mg
  • $ 278.00
  • Sigma-Aldrich
  • R(+)-UH-301 hydrochloride solid
  • 5mg
  • $ 1170.00
  • American Custom Chemicals Corporation
  • R(+)-UH-301 HYDROCHLORIDE 95.00%
  • 5MG
  • $ 1665.63
  • American Custom Chemicals Corporation
  • R(+)-UH-301 HYDROCHLORIDE 95.00%
  • 1MG
  • $ 807.08
Total 3 raw suppliers
Chemical Property of (R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin Edit
Chemical Property:
  • Vapor Pressure:2.22E-06mmHg at 25°C 
  • Boiling Point:382oC at 760 mmHg 
  • Flash Point:184.8oC 
  • PSA:23.47000 
  • LogP:3.51060 
  • Solubility.:H2O: slightly soluble 
  • XLogP3:4.2
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:5
  • Exact Mass:265.18419255
  • Heavy Atom Count:19
  • Complexity:268
Purity/Quality:

99.90% *data from raw suppliers

R(+)-UH-301 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:
Useful:
  • Canonical SMILES:CCCN(CCC)C1CCC2=C(C=CC(=C2C1)O)F
  • Isomeric SMILES:CCCN(CCC)[C@@H]1CCC2=C(C=CC(=C2C1)O)F
  • Uses R(+)-UH-301 hydrochloride is a 5-HT1A serotonin receptor agonist.
Technology Process of (R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin

There total 9 articles about (R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 8 steps
1: Tl(NO3)3 / methanol
2: aq. HCl / diethyl ether
3: benzene
4: NaCNBH3 / methanol
6: H2 / Pd/C / methanol
7: K2CO3 / acetonitrile
8: 48percent HBr / 120 °C
With hydrogenchloride; hydrogen bromide; hydrogen; sodium cyanoborohydride; potassium carbonate; thallium(III) nitrate; palladium on activated charcoal; In methanol; diethyl ether; acetonitrile; benzene;
DOI:10.1021/jm00168a002
Guidance literature:
Multi-step reaction with 9 steps
1: dimethylsulfoxide
2: Tl(NO3)3 / methanol
3: aq. HCl / diethyl ether
4: benzene
5: NaCNBH3 / methanol
7: H2 / Pd/C / methanol
8: K2CO3 / acetonitrile
9: 48percent HBr / 120 °C
With hydrogenchloride; hydrogen bromide; hydrogen; sodium cyanoborohydride; potassium carbonate; thallium(III) nitrate; palladium on activated charcoal; In methanol; diethyl ether; dimethyl sulfoxide; acetonitrile; benzene;
DOI:10.1021/jm00168a002
Guidance literature:
Multi-step reaction with 6 steps
1: benzene
2: NaCNBH3 / methanol
4: H2 / Pd/C / methanol
5: K2CO3 / acetonitrile
6: 48percent HBr / 120 °C
With hydrogen bromide; hydrogen; sodium cyanoborohydride; potassium carbonate; palladium on activated charcoal; In methanol; acetonitrile; benzene;
DOI:10.1021/jm00168a002
Refernces Edit
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