1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol

Base Information

Chemical Name:1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol
CAS No.:128104-25-6
Molecular Formula:C17H14BrFN2O
Molecular Weight:361.213
Hs Code.:
ChEMBL ID:CHEMBL110223
DSSTox Substance ID:DTXSID50874894
Nikkaji Number:J491.804E

Synonyms:128104-25-6;CHEMBL110223;SCHEMBL9200907;DTXSID50874894;1H-IMIDAZOLE-1-ETHANOL, _-(4-BROMOPHENYL)-_-(4-F

Suppliers and Price of 1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:360.02735
Heavy Atom Count:22
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(CN2C=CN=C2)(C3=CC=C(C=C3)Br)O)F

Technology Process of 1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol

There total 3 articles about 1-(4-Bromophenyl)-1-(4-fluorophenyl)-2-imidazol-1-ylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 288-32-4
1H-imidazole

: 128104-19-8
2-(4-fluorophenyl)-2-(4-bromophenyl)-oxirane

: 128104-25-6
1-(4-fluorophenyl)-1-(4-bromophenyl)-2-(1-imidazolyl)-ethanol

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm00095a009

Reference yield:

: 22480-64-4
4-bromophenyllithium

: 128104-25-6
1-(4-fluorophenyl)-1-(4-bromophenyl)-2-(1-imidazolyl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: 65 percent / t-BuOK / dimethylformamide / 90 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a009

Reference yield:

: 456-04-2
2-Chloro-4'-fluoroacetophenone

: 128104-25-6
1-(4-fluorophenyl)-1-(4-bromophenyl)-2-(1-imidazolyl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: 65 percent / t-BuOK / dimethylformamide / 90 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a009