Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-

Base Information

• Chemical Name: Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-
• CAS No.: 128535-90-0
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol file: 128535-90-0.mol

Synonyms:(R)-2-Amino-1-(4-chloro-phenyl)-ethanol;(R)-2-(4-chloro-phenyl)-2-hydroxy-ethylamine;

Chemical Property of Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-

Chemical Property:

• Melting Point: 94-95 °C
• Boiling Point: 319.8±27.0 °C(Predicted)
• PSA: 46.25000
• Density: 1.260±0.06 g/cm3(Predicted)
• LogP: 2.03240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-

There total 10 articles about Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R)-2-azido-1-(4-chlorophenyl)ethan-1-ol → (R)-2-amino-1-(4-chlorophenyl)ethanol (128535-90-0)

Guidance literature:

With hydrogen; sodium hydroxide; In aq. phosphate buffer; water; at 30 ℃; for 4h; under 7500.75 Torr; pH=9; Green chemistry;

DOI:10.1039/c3gc41666f

Reference yield:

(R)-(+)-4-chloromandelonitrile (13312-83-9,96523-99-8,106863-47-2,97070-79-6) → (R)-2-amino-1-(4-chlorophenyl)ethanol (128535-90-0)

Guidance literature:

(R)-(+)-4-chloromandelonitrile; With borane-THF; In tetrahydrofuran; at 20 ℃; for 3h; Heating / reflux;

With methanol; In tetrahydrofuran; for 0.333333h;

Reference yield:

N-(2-(4-chlorophenyl)-2-oxoethyl)acetamide (6660-08-8) → (R)-2-amino-1-(4-chlorophenyl)ethanol (128535-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O; ethanol / 504 h / 32 °C / baker's yeast, sucrose

2: 10percent aq. HCl / methanol

With hydrogenchloride; In methanol; ethanol; water;

DOI:10.1246/bcsj.66.1216

upstream raw materials:

N-[(R)-2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-acetamide

N-(2-(4-chlorophenyl)-2-oxoethyl)acetamide

N-(4-chloro-β-hydroxy-phenethyl)-acetamide

4-chlorophenacylamine hydrochloride

Downstream raw materials:

(R)-2-(4-chloro-phenyl)-2-hydroxy-ethylamine hydrochloride

(R)-5-(4-chlorophenyl)oxazolidin-2-one