6660-08-8

Upstream product

• 7644-03-3 2-amino-1-(4-chlorophenyl)ethanone 
• 127-09-3 sodium acetate 
• 5467-71-0 4-chlorophenacylamine hydrochloride 
• 108-24-7 acetic anhydride 
• 937-20-2 p-chlorophenacyl chloride 
• 75-36-5 acetyl chloride 
• 109472-48-2 acetylamino-(4-chloro-benzoyl)-malonic acid di-tert-butyl ester 

Downstream Products

• 1019974-35-6 C₂₀H₁₉ClN₂O₅ 
• 7411-58-7 dichloroacetic acid-[(1RS,2RS)-2-(4-chloro-phenyl)-2-hydroxy-1-hydroxymethyl-ethylamide] 
• 50731-32-3 (1RS,2RS)-2-amino-1-(4-chloro-phenyl)-propane-1,3-diol 
• 100129-78-0 N-[(1RS,2RS)-2-(4-chloro-phenyl)-2-hydroxy-1-hydroxymethyl-ethyl]-acetamide 
• 127720-33-6 7-(4-Chloro-phenyl)-8-cyano-1-ethyl-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 127720-43-8 2-{[4-(4-Chloro-phenyl)-3-cyano-1H-pyrrol-2-ylamino]-methylene}-malonic acid diethyl ester 
• 127720-39-2 7-(4-Chloro-phenyl)-8-cyano-1-ethyl-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 
• 127720-26-7 7-(4-Chloro-phenyl)-8-cyano-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 120450-07-9 2-amino-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 
• 149285-96-1 N-[(R)-2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-acetamide 
• 25594-98-3 2-methyl-5-(3′-methylphenyl)oxazole 
• 149342-40-5 N-(4-chloro-β-hydroxy-phenethyl)-acetamide 
• 792934-48-6 N-[2-(4-chloro-phenyl)-1-hydroxymethyl-2-oxo-ethyl]-acetamide 
• 128535-90-0 (R)-2-amino-1-(4-chlorophenyl)ethanol 

Relevant academic research and scientific papers

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

MODULATION OF PROTEIN TRAFFICKING

Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.

Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.

Synthesis of 4-oxopyrrolopyrimidine-3-carboxylic acid derivatives as potential antimicrobial agents

A route for the synthesis of various derivatives of 4-oxopyrrolopyrimidine-3-carboxylic acid from 2-amino-3-cyano-4,5-dimethylpyrrole and 2-amino-3-cyano-4-arylpyrroles is described.

Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them

A process for producing threo-3-amino-2-hydroxybutanoylaminoacetic acids comprises the steps of allowing to react a starting compound represented by the general formula: STR1 wherein R1 represents a naphthyl or a group of the formula: STR2 in which R6 and R7 represent individually hydrogen, halogen, amino or a protected amino, hydroxy or a protected hydroxy, a lower alkoxy or a lower alkyl and R2 represents a protected amino, with a starting compound represented by the general formula: STR3 wherein R3 represents hydrogen or an ester residue, to obtain threo-3-protected amino-2-hydroxy-4-oxobutanoic acid or its ester represented by the general formula: STR4 wherein R1, R2 and R3 have the same meanings as above, and then reducing the same into threo-3-protected amino-2-hydroxybutanoic acid or its ester represented by the general formula: STR5 wherein R1, R2 and R3 have the same meanings as above, and further converting the above compound into 3-amino-2-hydroxybutanoic acid represented by the general formula: STR6 wherein R2 ' represents amino or a protected amino, thereafter condensing the same, in a conventional manner for forming a peptide coupling, with a compound represented by the general formula: STR7 wherein R4 represents an alkyl having 3-4 carbon atom or 3-guanidinopropyl, while previously protecting as required those groups not relevant to the reaction, and removing the protecting groups for the functional groups to produce threo-3-amino-2-hydroxybutanoylaminoacetic acids represented by the general formula: STR8 wherein R1 and R4 have the same meanings as above. This invention also provides the compounds represented by the general formula (III) as novel intermediates for the above aimed compounds and a process for producing the intermediates.