6660-08-8

Basic information

• Product Name: N-[2-(4-chlorophenyl)-2-oxoethyl]acetamide
• CAS NO: 6660-08-8
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.6449
• Mol File: 6660-08-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 441.6°C at 760 mmHg
• Flash Point: 220.8°C
• Density: 1.231g/cm³
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: N-[2-(4-chlorophenyl)-2-oxoethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-chlorophenyl)-2-oxoethyl]acetamide(6660-08-8)
• EPA Substance Registry System: N-[2-(4-chlorophenyl)-2-oxoethyl]acetamide(6660-08-8)

Safety Data

• Hazardous Substances Data: 6660-08-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 7644-03-3 2-amino-1-(4-chlorophenyl)ethanone 
• 5467-71-0 4-chlorophenacylamine hydrochloride 
• 937-20-2 p-chlorophenacyl chloride 
• 75-36-5 acetyl chloride 
• 109472-48-2 acetylamino-(4-chloro-benzoyl)-malonic acid di-tert-butyl ester 
• 127-09-3 sodium acetate 

Downstream Products

• 1019974-35-6 C₂₀H₁₉ClN₂O₅ 
• 7411-58-7 dichloroacetic acid-[(1RS,2RS)-2-(4-chloro-phenyl)-2-hydroxy-1-hydroxymethyl-ethylamide] 
• 50731-32-3 (1RS,2RS)-2-amino-1-(4-chloro-phenyl)-propane-1,3-diol 
• 100129-78-0 N-[(1RS,2RS)-2-(4-chloro-phenyl)-2-hydroxy-1-hydroxymethyl-ethyl]-acetamide 
• 127720-33-6 7-(4-Chloro-phenyl)-8-cyano-1-ethyl-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 127720-43-8 2-{[4-(4-Chloro-phenyl)-3-cyano-1H-pyrrol-2-ylamino]-methylene}-malonic acid diethyl ester 
• 127720-39-2 7-(4-Chloro-phenyl)-8-cyano-1-ethyl-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 
• 127720-26-7 7-(4-Chloro-phenyl)-8-cyano-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 149285-96-1 N-[(R)-2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-acetamide 
• 128535-90-0 (R)-2-amino-1-(4-chlorophenyl)ethanol 
• 149285-94-9 Acetic acid (S)-2-acetylamino-1-(4-chloro-phenyl)-ethyl ester 
• 128535-89-7 (S)-(+)-2-amino-1-(p-chlorophenyl)ethanol 
• 120450-07-9 2-amino-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 
• 25594-98-3 2-methyl-5-(3′-methylphenyl)oxazole 

Relevant articles and documents

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.

Synthesis of 4-oxopyrrolo[1,2-a]pyrimidine-3-carboxylic acid derivatives as potential anitimicrobial agents

-