7-Amino-5-benzyl-5-azaspiro[2.4]heptane

Base Information

• Chemical Name: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane
• CAS No.: 129306-07-6
• Molecular Formula: C13H18N2
• Molecular Weight: 202.299
• Mol file: 129306-07-6.mol

Synonyms:5-phenylmethyl-5-azaspiro[2.4]heptan-7-amine;7-amino-5-benzyl-5-azaspiro[2.4]heptane;7-amino-5-benzyl-5-azaspiro[2,4]heptane;

Chemical Property of 7-Amino-5-benzyl-5-azaspiro[2.4]heptane

Chemical Property:

• PSA: 29.26000
• LogP: 2.24790

Purity/Quality:

97% ^*data from raw suppliers

5-BENZYL-5-AZASPIRO-[2.4]-HEPTAN-7-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Amino-5-benzyl-5-azaspiro[2.4]heptane

There total 8 articles about 7-Amino-5-benzyl-5-azaspiro[2.4]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(7E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one (129306-06-5) → 5-benzyl-5-azaspiro[2.4]heptane-7-amine (129306-07-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 60 ℃; for 5.5h;

Reference yield: 97.0%

4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane (129306-06-5) → 5-benzyl-5-azaspiro[2.4]heptane-7-amine (129306-07-6)

Guidance literature:

4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane; With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; for 5h; Reflux; Large scale;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.5h; Large scale;

Reference yield:

(7Z)-5-phenylmethyl-5-azaspiro[2.4]heptane-4,7-dione 7-O-methyloxime (1152111-03-9) → 5-benzyl-5-azaspiro[2.4]heptane-7-amine (129306-07-6)

Guidance literature:

(7Z)-5-phenylmethyl-5-azaspiro[2.4]heptane-4,7-dione 7-O-methyloxime; With lithium aluminium tetrahydride; In tetrahydrofuran; at 65 ℃; for 3h;

With water; sodium sulfate; In tetrahydrofuran;

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h;

upstream raw materials:

5-benzyl-7-hydroxyimino-5-azaspiro[2.4]heptane

(7Z)-5-phenylmethyl-5-azaspiro[2.4]heptane-4,7-dione 7-O-methyloxime

(7E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one

5-benzyl-5-azaspiro[2.4]heptane-4,7-dione

Downstream raw materials:

5-phenylmethyl-N-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-7-amine

N,N-dimethyl-5-phenylmethyl-5-azaspiro[2.4]heptan-7-amine

(7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan

5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane