129306-06-5

Basic information

• Product Name: (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one
• Synonyms: (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one;5-Azaspiro[2.4]heptane-4,7-dione, 5-(phenylmethyl)-, 7-oxime
• CAS NO: 129306-06-5
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.26246
• Mol File: 129306-06-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 490.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 11.24±0.20(Predicted)
• CAS DataBase Reference: (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one(129306-06-5)
• EPA Substance Registry System: (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one(129306-06-5)

Safety Data

• Hazardous Substances Data: 129306-06-5(Hazardous Substances Data)

Usage

General Description

(E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one is a chemical compound with the molecular formula C14H17NO2. It is a spiro compound, meaning it contains a unique five-membered ring structure. (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one has a benzyl group attached to the nitrogen atom and a hydroxyimino group attached to one of the carbon atoms in the ring. It is commonly used in organic synthesis and pharmaceutical research, where it may have potential applications due to its unique structure and properties. Additionally, it may also have potential biological activities that make it of interest for further study in medicinal chemistry and drug development.

Upstream product

• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 
• 331443-52-8 N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide 
• 147011-39-0 1-acetyl-N-[benzyl]cyclopropane-1-carboxamide 
• 882-36-0 N-benzyl-3-oxobutanamide 

Downstream Products

• 129306-07-6 5-benzyl-5-azaspiro[2.4]heptane-7-amine 
• 129306-13-4 5-phenylmethyl-N-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-7-amine 
• 152513-88-7 (7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan 
• 144282-35-9 5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane 
• 1432056-70-6 5-benzyl-7(S)-tert-butoxycarbonylamino-5-azaspiro[2,4]heptane 

Relevant articles and documents

A 5-benzyl -7 (S)-tert-butoxycarbonylamino-5-azaspiro [2,4] heptane preparation method of

The invention discloses a preparation method for 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. The method comprises the following steps: reacting benzoylamide acetoacetate as a raw material with 1,2-dichloroethane to obtain 3-cyclopropyl benzoylamide acetoacetate, brominating 3-cyclopropyl benzoylamide acetoacetate by NBS (n-bromosuccinimide) to obtain 1-bromo-3-cyclopropyl benzoylamide acetoacetate, cyclizing under alkaline conditions to obtain 5-benzyl-5-aza-spiro[2,4]heptane-4,7-diketone, further reacting with hydroxylamine hydrochloride to form an oxime compound-4-oxo-5-benzyl-7-oximido-5-aza-spiro[2,4]heptane, reducing by NaBH4 and boron trifluoride diethyl etherate to obtain 5-benzyl-7-amino-5-aza-spiro[2,4]heptane, performing chiral resolution by a resolving agent-L-camphorsulfonic acid to obtain 5-benzyl-7(S)-amino-5-aza-spiro[2,4]heptane, and reacting with di-tert-butyl dicarbonate ester to obtain 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. According to the method, an intermediate body-carbonyl does not need protection, raw materials are easy to get, a process route is simple, and the method is suitable for industrial production.

SUBSTITUTED ALKYNYL PYRIDINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl pyridine compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.