4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester

Base Information

Chemical Name:4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester
CAS No.:129688-97-7
Molecular Formula:C20H15BrF2N2O5
Molecular Weight:481.25
Hs Code.:

4-Isoquinolinecarboxylic acid,
4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,
3,4-tetrahydro-1,3-dioxo-, methyl ester

Synonyms:

Suppliers and Price of 4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester

There total 4 articles about 4-Isoquinolinecarboxylic acid, 4-(2-amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2, 3,4-tetrahydro-1,3-dioxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2-[(4-bromo-2-fluorophenyl)methyl]-4-cyanomethyl-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic acid methyl ester

: 129688-97-7
4-(2-Amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic Acid Methyl Ester

Guidance literature:: In methanol; hexane; Dimethyl ether;

Reference yield:

: 1026470-02-9
2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester

: 129688-97-7
4-(2-Amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic Acid Methyl Ester

Guidance literature:: With ammonia; In tetrahydrofuran;
DOI:10.1021/jm00039a018

Reference yield:

: 129688-85-3
2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

: 129688-97-7
4-(2-Amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic Acid Methyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: NH₃ / tetrahydrofuran

With thionyl chloride; ammonia; In tetrahydrofuran;
DOI:10.1021/jm00039a018