129688-85-3

Downstream Products

• 129688-97-7 4-(2-Amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic Acid Methyl Ester 
• 155407-44-6 2-(4-Bromo-2-fluoro-benzyl)-4-[(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 
• 1027994-36-0 2-(4-Bromo-2-fluoro-benzyl)-4-butylcarbamoylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 
• 1027256-19-4 2-(4-Bromo-2-fluoro-benzyl)-6-fluoro-1,3-dioxo-4-propylcarbamoylmethyl-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 
• 1026597-62-5 2-(4-Bromo-2-fluoro-benzyl)-6-fluoro-4-methylcarbamoylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 
• 1026470-02-9 2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 
• 139056-31-8 1'-Amino-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone 
• 133891-93-7 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid 

Relevant academic research and scientific papers

SPIRO-LACTAMS AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to spiro-lactams and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties w

1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

This invention relates to 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones of structural formula (I) STR1 wherein: R1 and R2 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, lower alko

SPIRO-PYRIDAZINES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to spiro-pyridazines, to processes for their preparation, to methods for using the compounds, and to pharmaceutical prepartions thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or

ISOQUINOLINE ACETIC ACIDS AND ACETYL CARBAMATES USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to isoquinoline acetic acids and acetyl carbamates and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for thetreatment of diabetes mellitus and associated conditions

N'-ALKYL-SPIRO-ISOQUINOLINE-PYRROLIDINE TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical perparations thereof. The compoun

ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones, represented by formula (I): to processes for the preparation, to methods for using the compounds, and to pharmaceutical preparations t

SPIRO-ISOQUINOLINE-PYRROLIDINE TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS

This invention relates to spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention of diabetes mellitus associated complications