Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI)

Base Information

Chemical Name:Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI)
CAS No.:129750-61-4
Molecular Formula:C12H21NSi
Molecular Weight:207.38700
Hs Code.:
Mol file:129750-61-4.mol

Synonyms:2-[(tert-Butyl-dimethyl-silanyl)-methyl]-pyridine;2-tert-butyldimethylsilylmethylpyridine;

Suppliers and Price of Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI)

Chemical Property:

PSA：12.89000
LogP:3.93820

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI)

There total 1 articles about Pyridine,2-[[(1,1-dimethylethyl)dimethylsilyl]methyl]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 109-06-8
α-picoline

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129750-61-4
2-((tert-butyldimethylsilyl)methyl)pyridine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h;
DOI:10.1016/S0040-4039(00)98806-3

Reference yield: 97.0%

: 108-86-1,52753-63-6
bromobenzene

: 129750-61-4
2-((tert-butyldimethylsilyl)methyl)pyridine

: 2-((tert-butyldimethylsilyl)(phenyl)methyl)pyridine

Guidance literature:: With palladium diacetate; lithium hexamethyldisilazane; nixantphos; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.1c00677

Reference yield: 92.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 129750-61-4
2-((tert-butyldimethylsilyl)methyl)pyridine

: 1334723-67-9
2-((tert-butyldimethylsilyl)(4-methoxyphenyl)methyl)pyridine

Guidance literature:: 2-((tert-butyldimethylsilyl)methyl)pyridine; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

1-bromo-4-methoxy-benzene; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 50 ℃; for 11h; Inert atmosphere;
DOI:10.1002/anie.201103074