1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate

Base Information

Chemical Name:1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate
CAS No.:129822-40-8
Molecular Formula:C12H16FNO2
Molecular Weight:225.263
Hs Code.:
DSSTox Substance ID:DTXSID301210750
Nikkaji Number:J416.451B

Synonyms:SCHEMBL8292291;DTXSID301210750;AKOS014476160;129822-40-8;1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate

Suppliers and Price of 1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:225.11650692
Heavy Atom Count:16
Complexity:250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)F)NC(=O)OC(C)(C)C

Technology Process of 1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate

There total 1 articles about 1,1-Dimethylethyl N-(4-fluoro-2-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 452-71-1
4-fluor-2-methylaniline

: 129822-40-8
tert-butyl (4-fluoro-2-methylphenyl)carbamate

Guidance literature:

Reference yield:

: 129822-40-8
tert-butyl (4-fluoro-2-methylphenyl)carbamate

: 56341-41-4
5-fluoroindol-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min

2: 10percent HCl / ethanol / 0.25 h / Heating

With hydrogenchloride; sec.-butyllithium; In ethanol;
DOI:10.1055/s-1991-26597

Reference yield:

: 78906-15-7,114413-26-2,124150-87-4,123237-62-7
tert-butyldimethylsilyl (S)-glycidyl ether

: 129822-40-8
tert-butyl (4-fluoro-2-methylphenyl)carbamate

: C₂₁H₃₆FNO₄Si

Guidance literature:: tert-butyl (4-fluoro-2-methylphenyl)carbamate; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -40 ℃; for 0.5h; Inert atmosphere;

tert-butyldimethylsilyl (S)-glycidyl ether; In tetrahydrofuran; cyclohexane; at -40 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.09.025