2-Propen-1-one, 3-(4-hydroxyphenyl)-1-[2-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phen yl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-

Base Information

• Chemical Name: 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-[2-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phen yl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
• CAS No.: 130064-27-6
• Molecular Formula: C₃₁H₃₂O₇
• Molecular Weight: 516.591
• Mol file: 130064-27-6.mol

Synonyms:

Chemical Property of 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-[2-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phen yl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-[2-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phen yl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-

There total 2 articles about 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-[2-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phen yl]-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,4'-trihydroxy deoxybenzoin (17720-60-4,423150-69-0) → 1-<2-hydroxy-4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-3-(4-hydroxyphenyl)prop-2-en-1-one (130064-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: concd. HCl / 4 h / 0 °C

2: piperidine / benzene / Heating

With piperidine; hydrogenchloride; In benzene;

DOI:10.1021/jm00174a020

Reference yield:

1-(2-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone (130064-21-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1-<2-hydroxy-4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-3-(4-hydroxyphenyl)prop-2-en-1-one (130064-27-6) + 2-(4-hydroxyphenyl)-3-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-7-<(tetrahydropyran-2-yl)oxy>-2,3-dihydro-4H-1-benzopyran-4-one (130064-26-5)

Guidance literature:

With piperidine; In benzene; Heating;

DOI:10.1021/jm00174a020 DOI:10.1016/S0223-5234(97)87540-X

Reference yield:

1-<2-hydroxy-4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-3-(4-hydroxyphenyl)prop-2-en-1-one (130064-27-6) → 2,3-bis(4-hydroxyphenyl)-7-hydroxy-2H-1-benzopyran (130064-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride / ethanol / 12 h

2: aq. HCl / ethanol / 0.33 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00174a020

upstream raw materials:

1-(2-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

4-hydroxy-benzaldehyde

2,4,4'-trihydroxy deoxybenzoin

Downstream raw materials:

2,3-bis(4-hydroxyphenyl)-7-hydroxy-2H-1-benzopyran

1-[2-(4-{7-(Tetrahydro-pyran-2-yloxy)-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-2H-chromen-2-yl}-phenoxy)-ethyl]-piperidine