10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Base Information

Chemical Name:10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate
CAS No.:65202-60-0
Molecular Formula:C12H19NO6
Molecular Weight:273.286
Hs Code.:
European Community (EC) Number:265-616-6
Nikkaji Number:J307.332G
Mol file:65202-60-0.mol

Synonyms:65202-60-0;10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate;SCHEMBL3619623;JCSIMGKOBJIXLB-UHFFFAOYSA-N;NS00055984;EN300-19059982

Suppliers and Price of 10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Chemical Property:

Vapor Pressure:1.9E-08mmHg at 25°C
Boiling Point:425.9°Cat760mmHg
Flash Point:211.4°C
PSA：74.30000
Density:1.32g/cm³
LogP:0.31880
XLogP3:-0.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:273.12123733
Heavy Atom Count:19
Complexity:352

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1CCN(CC12OCCO2)C(=O)OC

Technology Process of 10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

There total 5 articles about 10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 65202-59-7,76508-78-6
4-ethyl 1-methyl 3-oxopiperidine-1,4-dicarboxylate

: 107-21-1
ethylene glycol

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 72h; Reflux;
DOI:10.1021/jm500462x

Reference yield: 65.0%

: 65202-59-7,76508-78-6
4-ethyl 1-methyl 3-oxopiperidine-1,4-dicarboxylate

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In ethylene glycol; ethyl acetate; benzene;

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / water; ethanol / 48 h / 2327.23 Torr

2: potassium carbonate / 1.5 h / 0 - 20 °C

3: toluene-4-sulfonic acid / benzene / 72 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; toluene-4-sulfonic acid; In ethanol; water; benzene;
DOI:10.1021/jm500462x