Refernces
10.1002/adfm.201103147
The research focuses on the development of a new family of cationic charged biocompatible hybrid hydrogels, based on arginine unsaturated poly(ester amide) (Arg-UPEA) and Pluronic diacrylate (Pluronic-DA), which were fabricated through UV photocrosslinking in an aqueous medium. The purpose of this study was to improve the cellular interactions of synthetic hydrogels for potential biomedical applications by introducing cationic Arg-UPEA, which possesses biocompatibility and cationic properties. The conclusions drawn from the research indicate that the incorporation of Arg-UPEA into Pluronic-DA hydrogels significantly enhanced cell attachment, proliferation, and viability of both Detroit 539 human fibroblasts and bovine aortic endothelial cells. The chemicals used in the process include Pluronic F127, acryloyl chloride, triethylamine, Irgacure 2959 (as a photoinitiator), L-arginine, p-toluenesulfonic acid monohydrate, fumaryl chloride, ethylene glycol, 1,3-propanediol, 1,4-butanediol, 1,6-hexanediol, and p-nitrophenol, among others. These chemicals were utilized in the synthesis of the hydrogel precursors and for the characterization of their physicochemical properties.
10.1055/s-2007-990834
The research focuses on the development of a simple and efficient method for synthesizing new mono- and bis([1,2,4]-oxadiazol)benzaldehyde building blocks, which are valuable in organic chemistry for a variety of applications. The purpose of this study was to create a high-yielding, five-step procedure with minimal and straightforward purifications, starting from readily available benzamidoxime, derived from 4-cyanobenzaldehyde. The conclusion of the research is that the team successfully developed a general method for synthesizing these compounds with aromatic and aliphatic linkers, yielding overall yields between 66% and 80%. Key chemicals used in the process include 4-cyanobenzaldehyde, ethylene glycol, p-toluenesulfonic acid, hydroxylamine hydrochloride, sodium carbonate, pyridine, phenylacetyl chloride, and various dicarboxylic acids or acid dichlorides to introduce different linkers. The final products, the mono- and bis([1,2,4]-oxadiazol)benzaldehydes, were obtained through a series of reactions involving O-acylation, acetal deprotection, and cyclization steps.
10.1016/s0022-328x(97)00456-7
The study investigates the formation of dimeric and trimeric molybdenum(II) complexes containing 2-substituted 3-bonded butadienyl bridging ligands. The starting material used is [MoCI(CO)2(@-CH2(COCI)C=CH2)phen] (phen = 1,10-phenanthroline) (1). When 1 reacts with 1,2-ethanediol or N,N'-diethylethylenediamine in a 2:1 mole ratio, dimeric complexes [MoCI(CO)2(@-CH/(COACH2)C=CH2)phen]2 are formed, where A represents the substituent group (A = O for ester, A = NEt for amide). Reactions with hydroquinone or 1,4-phenylenediamine yield monomeric complexes [MoCI(CO)2(@-CH2(COA)C=CH2)phen], while dimeric complexes are isolated from reactions involving 4,4'-ethylenedianiline or p-xylylenediamine. Attempts to prepare a novel complex bridged by three linked amide substituted butadienyl groups using diethylenetriamine were unsuccessful. However, reaction of 1 with triethanolamine or tris(2-aminoethyl)amine in a 3:1 mole ratio gives trimeric complexes [MoCI(CO)2(~/a-CH2(COACH2CH2)C=CH2)phen]3 N (A = O, NH) in good yield. The study establishes conditions for the formation of these complexes and examines the boundaries of dimer and trimer formation using various bifunctional and trifunctional reagents.
10.1016/j.molstruc.2007.01.064
The research focuses on the synthesis, structure, and luminescent properties of a novel 3D porous metal-organic framework (MOF) with rutile topology, denoted as Cd(CTC)(HPDA)·(H2O) (1). The MOF was synthesized using 1,3-propanediamine (PDA) as a template, with cadmium chloride dihydrate and cis,cis-1,3,5-cyclohexanetricarboxylate (CTC) as reactants. The synthesis involved mixing these compounds in N,N-dimethylformamide, ethylene glycol, and water, followed by the slow diffusion of PDA at 65°C for five days, yielding colorless block-shaped crystals. The product was characterized using X-ray crystallography, which revealed a 3D network with quadrangular channels. The structure was further analyzed using thermogravimetric analysis (TGA), differential thermal analysis (DTA), powder X-ray diffraction (XRD), inductively coupled plasma (ICP) analysis, and infrared (IR) spectroscopy. The compound exhibited intense fluorescence at 364 nm upon excitation at 240 nm at room temperature, indicating potential as a photoactive material. The research was supported by several funding agencies and the crystallographic data was deposited with the Cambridge Crystallographic Data Centre.
10.1016/j.tet.2005.09.079
The research aims to develop a general, acid-free method for the acetalization of various aldehydes and ketones using N,N-bis[3,5-bis(trifluoromethyl)phenyl] thiourea as a neutral, double hydrogen bonding organocatalyst. The purpose of this method is to provide a mild and highly practical approach for the synthesis of acetals, which are important intermediates and protecting groups in synthetic and carbohydrate chemistry, particularly for acid-labile substrates. The study successfully demonstrated that a wide range of aliphatic and aromatic carbonyl compounds, including saturated, aromatic, and unsaturated aldehydes and ketones, could be efficiently converted into their respective acetals at very low catalyst loadings (0.01–1 mol%) and at room temperature, yielding products in 65–99% yield with turnover frequencies around 600 h?1. The chemicals used in the process include various aldehydes and ketones, N,N-bis[3,5-bis(trifluoromethyl)phenyl] thiourea, ethanol, 1,2-ethanediol, and alkyl orthoformates, among others. The conclusions of the research highlight the high efficiency and broad applicability of the developed organocatalytic acetalization method, which operates at the lowest catalyst loadings reported for an organocatalytic reaction to date and is particularly beneficial for substrates that are sensitive to acidic conditions.
10.1055/s-1982-29807
The research aims to optimize the synthesis of 2-bromo-3-methyl-2-cyclopentenone 1,2-ethanediyl acetal (1) and its precursors, including 3-methyl-2-cyclopentenone (5) and 2-bromo-3-methyl-2-cyclopentenone (8), as these compounds are important for the generation of organolithium derivatives used in natural products synthesis. The study presents improved methods for preparing these compounds, focusing on high yields and purity. Key chemicals used include 3-methyl-2-cyclopentenone, bromine, sodium hydrogen carbonate, p-toluenesulfonic acid, and 1,2-ethanediol. The researchers developed a purification method for 3-methyl-2-cyclopentenone, achieving a 94% yield. They also optimized the bromination and acetalization processes, obtaining 2-bromo-3-methyl-2-cyclopentenone in 61% yield and the final acetal in 66% yield. The study concludes that the optimized procedures provide efficient and environmentally friendly methods for synthesizing these important intermediates, with all components isolated or recovered in high yields, minimizing waste and environmental impact.
Xn
