3-(2-Hydroxyphenyl)coumarin

Base Information

• Chemical Name: 3-(2-Hydroxyphenyl)coumarin
• CAS No.: 13130-21-7
• Molecular Formula: C15H10O3
• Molecular Weight: 238.243
• Mol file: 13130-21-7.mol

Synonyms:3-(2-Hydroxy-phenyl)-cumarin;3-(2'-Hydroxyphenyl)-2H-chromen-2-on;3-(2-Hydroxy-phenyl)-chromen-2-one;3-(2-hydroxyphenyl)coumarin;3-(2-hydroxy-phenyl)-coumarin;3-<2-Hydroxy-phenyl>-cumarin;

Chemical Property of 3-(2-Hydroxyphenyl)coumarin

Chemical Property:

• PSA: 50.44000
• LogP: 3.16560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Hydroxyphenyl)coumarin

There total 24 articles about 3-(2-Hydroxyphenyl)coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-phenylcumarin (955-10-2) → 3-(2-hydroxyphenyl)-2H-chromen-2-one (13130-21-7)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; In trifluoroacetic acid; at 90 ℃; for 1h; regioselective reaction;

DOI:10.1021/acs.joc.1c01097

Reference yield: 89.0%

3-(4-methoxyphenyl)coumarin (23000-33-1) → 3-(2-hydroxyphenyl)-2H-chromen-2-one (13130-21-7)

Guidance literature:

With hydrogenchloride;

Reference yield: 87.0%

(Z)-2-methoxy-α-(2-methoxyphenyl)cinnamic acid (42308-40-7) → 3-(2-hydroxyphenyl)-2H-chromen-2-one (13130-21-7)

Guidance literature:

With pyridine hydrochloride; at 170 ℃; for 2.5h;

upstream raw materials:

3-(2-methoxyphenyl)-2H-chromen-2-one

3-(4-methoxyphenyl)coumarin

(Z)-2-methoxy-α-(2-methoxyphenyl)cinnamic acid

ethyl (2-methoxyphenyl)(oxo)acetate

Downstream raw materials:

3-(2-acetoxy-phenyl)-coumarin

dihydroxy-stilbene