1H-Benzimidazol-5-ol, 2-(phenylmethyl)-

Base Information

Chemical Name:1H-Benzimidazol-5-ol, 2-(phenylmethyl)-
CAS No.:131336-23-7
Molecular Formula:C₁₄H₁₂N₂O
Molecular Weight:224.262
Hs Code.:
DSSTox Substance ID:DTXSID60349725
Wikidata:Q82125149
ChEMBL ID:CHEMBL1391474

Synonyms:1H-Benzimidazol-5-ol, 2-(phenylmethyl)-;131336-23-7;2-benzyl-5-hydroxybenzimidazole;Oprea1_281390;MLS000039825;2-benzyl-1H-benzimidazol-5-ol;CHEMBL1391474;DTXSID60349725;HMS2313L19;STK525752;AKOS005459310;SMR000039357

Suppliers and Price of 1H-Benzimidazol-5-ol, 2-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1H-Benzimidazol-5-ol, 2-(phenylmethyl)-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:224.094963011
Heavy Atom Count:17
Complexity:253

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC2=NC3=C(N2)C=C(C=C3)O

Technology Process of 1H-Benzimidazol-5-ol, 2-(phenylmethyl)-

There total 10 articles about 1H-Benzimidazol-5-ol, 2-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885-81-4
N-(4-ethoxy-2-nitrophenyl)acetamide

: 131336-23-7
2-benzyl-5⁽⁶⁾-hydroxybenzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: aq. hydrazine / Raney nickel

2: 6 h / 175 - 180 °C

3: aq. HBr / 20 h / Heating

With hydrogen bromide; hydrazine hydrate; nickel;
DOI:10.1007/BF00869526

Reference yield:

: 16133-49-6
5-methoxy-2-nitroaniline

: 131336-23-7
2-benzyl-5⁽⁶⁾-hydroxybenzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h

2: hydrogen; palladium / ethanol

3: sulfuric acid / i-Amyl alcohol / 18 h

4: hydrogen bromide / 80 °C

With sulfuric acid; hydrogen bromide; hydrogen; palladium; triethylamine; In ethanol; i-Amyl alcohol; dichloromethane;
DOI:10.1016/j.bmcl.2012.01.108

Reference yield:

: 1272902-62-1
C₁₅H₁₆N₂O₂

: 131336-23-7
2-benzyl-5⁽⁶⁾-hydroxybenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / i-Amyl alcohol / 18 h

2: hydrogen bromide / 80 °C

With sulfuric acid; hydrogen bromide; In i-Amyl alcohol;
DOI:10.1016/j.bmcl.2012.01.108