885-81-4

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-ethoxy-2-nitrophenyl)acetamide is used as a chemical intermediate for the synthesis of pharmaceuticals, leveraging its nitro and acetamide functionalities for potential biological activities. Its unique molecular structure allows for the exploration of its properties and reactivity, which could be harnessed to create novel drugs with enhanced therapeutic effects and minimized side effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(4-ethoxy-2-nitrophenyl)acetamide serves as a valuable molecule for studying the chemical behavior and reactivity of nitrophenyl and acetamide compounds. Its synthesis and properties provide insights into the development of new drug candidates, potentially leading to the discovery of more effective and safer medications.
Used in Drug Development:
N-(4-ethoxy-2-nitrophenyl)acetamide is utilized in drug development as a key building block for the creation of new pharmaceutical agents. Its functional groups can be modified or combined with other molecules to design drugs with specific therapeutic targets, potentially resulting in treatments with improved efficacy and reduced toxicity for various diseases and conditions.

InChI:InChI=1/C10H12N2O4/c1-3-16-8-4-5-9(11-7(2)13)10(6-8)12(14)15/h4-6H,3H2,1-2H3,(H,11,13)

Upstream product

• 62-44-2 4-ethoxyacetanilide 
• 108-24-7 acetic anhydride 
• 156-43-4 4-Ethoxyaniline 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 56-23-5 tetrachloromethane 
• 64-17-5 ethanol 
• 59255-66-2 N-(tert-butoxycarbonyl)-4-ethoxyaniline 

Downstream Products

• 67169-91-9 N-(2-amino-4-ethoxyphenyl)acetamide 
• 1197-37-1 4-ethoxy-benzene-1,2-diamine 
• 616-86-4 2-nitro-4-ethoxyaniline 
• 1777-85-1 acetic acid-(4-ethoxy-2,3-dinitro-anilide) 
• 861086-17-1 acetic acid-(4-ethoxy-3-chloro-2-nitro-anilide) 
• 282547-59-5 6-ethoxy-8-nitro-quinoline 
• 745048-80-0 6-ethoxy-5-nitroquinoxaline 
• 89770-34-3 6-ethoxyquinoxaline 
• 603-84-9 2-chloro-3-nitrophenol 
• 846031-57-0 2-chloro-3-nitro-phenetole 
• 858855-42-2 4-ethoxy-3-chloro-2-nitro-aniline 
• 35739-45-8 4-ethoxy-2-nitro-1-phenylamine 
• 72546-12-4 4-Ethoxy-2-aminobenzolsulfonsaeure 
• 72546-14-6 4-Ethoxy-benzol-disulfonsaeure-(1,2) 

Relevant academic research and scientific papers

Visible-Light-Mediated Nitration of Protected Anilines

The photocatalytic nitration of protected anilines proceeds with riboflavin tetraacetate as an organic photoredox catalyst. Sodium nitrite serves as the NO2 source in this visible-light-driven room temperature reaction. Various nitroanilines are obtained in moderate to good yields without the addition of acid or stoichiometric oxidation agents. The catalytic cycle is closed by aerial oxygen as the terminal oxidant.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT

The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

Phototransformations of 6-X-5-nitroquinoxalines

Photophysical properties and photochemical activity of 6-X-5- nitroquinoxalines with electron-donor substituents (X = H, CH3, Cl, OC2H5, NH2) ortho to the nitro group were studied. The quantum yield of the formation of 5-hydroxyquinoxaline from the corresponding nitro derivative depends on the nature of the substituent and irradiation conditions. Phototransformations can go through nitro-nitrite rearrangement with the participation of two alternative T(nπ*) levels, depending on the size and electronic effects of the substituent. The latter factor is largely determined by the population on excitation of different charge-transfer states involving the nitro group.

Inhibition of Rat Hepatic Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives. Quantitative Structure-Activity Relationships

Eighty-two benzimidazole derivatives have been prepared and tested for the ability to inhibit cytochrome P-450 mediated enzyme activity (aminopyrine N-demethylase) from phenobarbitone-induced rat hepatic microsomes.Using physicochemical parameters and multiple regression analysis, we derived a quantitative structure-activity relationship (QSAR) that describes up to 87percent of the data variance in terms of hydrophobic and electronic effects and the molar refractivity of the substituent in the 2-position of the benzimidazole ring.