2-Chloro-2,2-difluoroacetamide

Base Information

• Chemical Name: 2-Chloro-2,2-difluoroacetamide
• CAS No.: 354-28-9
• Molecular Formula: C2H2ClF2NO
• Molecular Weight: 129.494
• Hs Code.: 2924199090
• European Community (EC) Number: 206-555-7
• NSC Number: 9448
• DSSTox Substance ID: DTXSID1059866
• Nikkaji Number: J193.829K
• Wikidata: Q81988978
• Mol file: 354-28-9.mol

Synonyms:Chlorodifluoroacetamide;2-Chloro-2,2-difluoroacetamide;354-28-9;Acetamide, 2-chloro-2,2-difluoro-;Difluorochloroacetamide;NSC 9448;EINECS 206-555-7;AI3-52633;NSC9448;Acetamide,2-difluoro-;C2H2ClF2NO;SCHEMBL751015;C2-H2-Cl-F2-N-O;DTXSID1059866;2-Chloro-2,2-difluoroacetamide #;NSC-9448;MFCD00039775;AKOS006223213;2-chloranyl-2,2-bis(fluoranyl)ethanamide;LS-08726;FT-0623641;A822794

Chemical Property of 2-Chloro-2,2-difluoroacetamide

Chemical Property:

• Vapor Pressure: 0.591mmHg at 25°C
• Melting Point: 79-81 °C(lit.)
• Refractive Index: 1.388
• Boiling Point: 188.7 °C at 760 mmHg
• PKA: 12.61±0.50(Predicted)
• Flash Point: 67.9 °C
• PSA: 43.09000
• Density: 1.529 g/cm³
• LogP: 1.00360
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 128.9792977
• Heavy Atom Count: 7
• Complexity: 93.7

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-2,2-difluoroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)(C(F)(F)Cl)N

Technology Process of 2-Chloro-2,2-difluoroacetamide

There total 5 articles about 2-Chloro-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dichlorotrifluoroethyl fluorosulfate (681-25-4) → 2-chloro-2,2-difluoroacetamide (354-28-9)

Guidance literature:

With ammonia; In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 0 ℃; for 15h;

DOI:10.1021/ja01472a020

Reference yield:

3,4-dibromo-1-chloro-1,1,3,4,4-pentafluoro-butan-2-one (664-11-9) → 2-chloro-2,2-difluoroacetamide (354-28-9)

Guidance literature:

With ammonia; In diethyl ether;

DOI:10.1007/BF00942892

Reference yield:

→ 2-chloro-2,2-difluoroacetamide (354-28-9)

Guidance literature:

With ethanol; ammonia;

upstream raw materials:

3,4-dibromo-1-chloro-1,1,3,4,4-pentafluoro-butan-2-one

1,2-dichlorotrifluoroethyl fluorosulfate

Downstream raw materials:

chlorodifluoroacetonitrile

Dichlorodifluoromethane

Chlorodifluoromethane

(4-chloro-phenyl)-(4-difluoromethoxy-phenyl)-methanone