(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID

Base Information

• Chemical Name: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID
• CAS No.: 132376-67-1
• Molecular Formula: C11H8O3
• Molecular Weight: 188.17900
• Mol file: 132376-67-1.mol

Synonyms:benzofuran-2-acrylic acid;

Chemical Property of (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID

Chemical Property:

• PSA: 50.44000
• LogP: 2.53060

Purity/Quality:

99% ^*data from raw suppliers

(2e)-3-(1-Benzofuran-2-Yl)acrylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID

There total 9 articles about (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(E)-ethyl 3-(2-benzofuryl)acrylate (125482-23-7) → (2E)-3-(1-benzofuran-2-yl)-2-propenoic acid (132376-67-1)

Guidance literature:

With potassium hydroxide; for 4h; Heating;

DOI:10.1002/chem.200501034

Reference yield: 84.0%

malonic acid (141-82-2) + 2-formylbenzo[b]furan (4265-16-1) → (2E)-3-(1-benzofuran-2-yl)-2-propenoic acid (132376-67-1)

Guidance literature:

With piperidine; pyridine; at 80 - 115 ℃; for 4h;

DOI:10.1080/10426500701557310

Reference yield:

1-benzofurane (271-89-6) → (2E)-3-(1-benzofuran-2-yl)-2-propenoic acid (132376-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / POCl₃ / 20 h / 100 °C

2: 90 percent / toluene / 2 h / Heating

3: 92 percent / aq. KOH / 4 h / Heating

With potassium hydroxide; trichlorophosphate; In toluene;

DOI:10.1002/chem.200501034

upstream raw materials:

malonic acid

2-formylbenzo[b]furan

ethyl 3-(benzo[b]furan-2-yl)propionate

(rac)-2-amino-3-benzofuran-2-yl-propionic acid

Downstream raw materials:

6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-benzyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(3-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Refernces

• 1、 Nishiyama, Takashi,Hatae, Noriyuki,Hayashi, Kaori,Obata, Manami,Taninaka, Kimiko,Yamane, Masahiro,Oda, Shota,Abe, Takumi,Ishikura, Minoru,Hibino, Satoshi,Choshi, Tominari. "One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via curtius rearrangement & microwave-assisted thermal electrocyclization". . p. 251 - 267. Retrieved 2017/07/28.
• 2、 Obushak, Mykola D.,Pokhodylo, Nazariy T.,Ostapiuk, Yuri V.,Matiychuk, Vasyl S.. "Synthesis of 3-substituted (6-[(e)-2-(1-benzofuran-2-yl)ethenyl][1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles". . p. 136 - 143. Retrieved 2008/12/23.