1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole

Base Information

• Chemical Name: 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole
• CAS No.: 132726-50-2
• Molecular Formula: C18H17NO
• Molecular Weight: 263.339
• Mol file: 132726-50-2.mol

Synonyms:1-(2-Methoxy-phenyl)-2-methyl-5-phenyl-1H-pyrrole;1-(2-Methoxy-phenyl)-2-methyl-5-phenyl-pyrrol;1-(2-methoxy-phenyl)-2-methyl-5-phenyl-pyrrole;

Chemical Property of 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole

Chemical Property:

• Melting Point: 68 - 69 °C
• PSA: 14.16000
• LogP: 4.46130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole

There total 3 articles about 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-Nitroanisole (91-23-6) + 1-phenylpentane-1,4-dione (583-05-1) → 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole (132726-50-2)

Guidance literature:

With indium; acetic acid; In toluene; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.05.113

Reference yield:

2-methoxy-phenylamine (90-04-0) + 1-phenylpentane-1,4-dione (583-05-1) → 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole (132726-50-2)

Guidance literature:

Reference yield:

benzaldehyde (100-52-7) → 1-(2-methoxyphenyl)-2-methyl-5-phenyl-1H-pyrrole (132726-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 75 °C

2: aq. phosphate buffer; acetonitrile / 23 °C / pH 7.2

With triethylamine; In aq. phosphate buffer; ethanol; acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1039/d0ra06962k

upstream raw materials:

2-methoxy-phenylamine

1-phenylpentane-1,4-dione

2-Nitroanisole

benzaldehyde