N-(1-benzylpiperidin-4-yl)-2-phenylacetamide

Base Information

• Chemical Name: N-(1-benzylpiperidin-4-yl)-2-phenylacetamide
• CAS No.: 132862-06-7
• Molecular Formula: C20H24N2O
• Molecular Weight: 308.423
• DSSTox Substance ID: DTXSID10384727
• Nikkaji Number: J989.181A
• Wikidata: Q82177057
• Pharos Ligand ID: 4F44APT1U3Z2
• ChEMBL ID: CHEMBL76895
• Mol file: 132862-06-7.mol

Synonyms:CHEMBL76895;N-(1-benzylpiperidin-4-yl)-2-phenylacetamide;132862-06-7;Maybridge3_003267;Benzeneacetamide, N-[1-(phenylmethyl)-4-piperidinyl]-;Oprea1_622701;SCHEMBL5862113;DTXSID10384727;HMS1440E11;BDBM50064947;STL256306;AKOS003356962;IDI1_014654;N-(1-benzyl-4-piperidyl)-2-phenylacetamide;N-(1-Benzylpiperidine-4-yl)-2-phenylacetamide;N-(1-Benzyl-piperidin-4-yl)-2-phenyl-acetamide

Chemical Property of N-(1-benzylpiperidin-4-yl)-2-phenylacetamide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 308.188863393
• Heavy Atom Count: 23
• Complexity: 351

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1NC(=O)CC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of N-(1-benzylpiperidin-4-yl)-2-phenylacetamide

There total 1 articles about N-(1-benzylpiperidin-4-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) + 4-amino-1-benzylpiperidine (50541-93-0) → N-(1-benzylpiperidin-4-yl)phenylacetamide (132862-06-7)

Guidance literature:

With dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) THF, 30 min, 2.) THF, RT, overnight;

DOI:10.1021/jm980032l

Reference yield: 90.0%

N-(1-benzylpiperidin-4-yl)phenylacetamide (132862-06-7) → 4-phenylacetamidopiperidine (75484-47-8)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 12h; under 2585.81 Torr;

DOI:10.1021/jm010384j

Reference yield:

N-(1-benzylpiperidin-4-yl)phenylacetamide (132862-06-7) → N-(1-benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2-phenyl-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / Pd(OH)2/C / methanol / 12 h / 2585.81 Torr

2: 68 percent / Et₃N / CH₂Cl₂ / 20 °C

With hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1021/jm010384j

upstream raw materials:

phenylacetic acid

4-amino-1-benzylpiperidine

Downstream raw materials:

4-phenylacetamidopiperidine

N-(1-phenethyl-piperidin-4-yl)-2-phenyl-acetamide

Refernces

• 1、 -. "COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES". Page 28. . Retrieved 2010/02/08.