2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-

Base Information

Chemical Name:2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-
CAS No.:133040-10-5
Molecular Formula:C22H23ClN2O2S
Molecular Weight:414.956
Hs Code.:

Synonyms:

Suppliers and Price of 2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-

There total 16 articles about 2-Thiophenepropanoic acid, a-[[2-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133485-47-9
methyl (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-2-<(2-thienyl)methyl>-2-propenoate

: 133040-10-5
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 25 ℃; for 2h;
DOI:10.1021/jm00099a013

Reference yield:

: methyl (E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]2-(2-thienyl)methyl-2-propenoate propenoate

: 133040-10-5
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: With sodium hydroxide; In ethanol;

Reference yield:

: 1124-65-8,15690-25-2,51019-83-1
3-(2-thienyl)-2-propenoic acid

: 133040-10-5
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / HCl / diethyl ether / 23 h / 20 - 50 °C

2: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 11 h / 2327.2 Torr / Ambient temperature

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

4: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

5: DBU / toluene / 1 h / 100 °C

6: 10percent aq. NaOH / ethanol / 2 h / 25 °C

With hydrogenchloride; dmap; sodium hydroxide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm00099a013