(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

Base Information

Chemical Name:(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide
CAS No.:133486-11-0
Molecular Formula:C₂₂H₂₄ClN₃OS
Molecular Weight:413.971
Hs Code.:

Synonyms:(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

Chemical Property:

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Technology Process of (E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

There total 10 articles about (E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1336-21-6
ammonium hydroxide

: 133040-10-5
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

: 133486-11-0
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

Guidance literature:: With thionyl chloride; In hexane; benzene;

Reference yield:

: 133485-47-9
methyl (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-2-<(2-thienyl)methyl>-2-propenoate

: 133486-11-0
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

Guidance literature:: With ammonium hydroxide; thionyl chloride;

Reference yield:

: 16862-05-8
methyl 3-(2-thienyl)propanoate

: 133486-11-0
(E)-3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenamide

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; ethyl acetate; toluene

2: dmap; acetic anhydride / dichloromethane; water

3: toluene

4: ammonium hydroxide; thionyl chloride

With dmap; ammonium hydroxide; n-butyllithium; thionyl chloride; acetic anhydride; diisopropylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;