N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride

Base Information

• Chemical Name: N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride
• CAS No.: 18483-57-3
• Molecular Formula: C19H26ClNO
• Molecular Weight: 319.8688
• Mol file: 18483-57-3.mol

Synonyms:N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride;ETHYLAMINE, N,N-DIMETHYL-2-(DI-(p-TOLYL)METHOXY)-, HYDROCHLORIDE;18483-57-3;LS-68112;Ethylamine, 2-(di-p-tolylmethoxy)-N,N-dimethyl-, hydrochloride

Chemical Property of N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 5.55E-06mmHg at 25°C
• Boiling Point: 380.2°Cat760mmHg
• Flash Point: 112°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 319.1702921
• Heavy Atom Count: 22
• Complexity: 253

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(C2=CC=C(C=C2)C)OCC[NH+](C)C.[Cl-]

Technology Process of N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride

There total 4 articles about N,N-Dimethyl-2-(di-(p-tolyl)methoxy)ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-methylphenylmagnesium bromide (4294-57-9) → di(p-tolyl)(dimethylaminoethoxy)methane hydrochloride (18483-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 144 h / Reflux

2: Acetyl bromide / benzene / 216 h / Reflux

3: 5,5-dimethyl-1,3-cyclohexadiene / 90 h / Reflux

With Acetyl bromide; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; benzene;

DOI:10.1007/s00044-011-9891-y

Reference yield:

4,4'-dimethylbenzhydrol (885-77-8) → di(p-tolyl)(dimethylaminoethoxy)methane hydrochloride (18483-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Acetyl bromide / benzene / 216 h / Reflux

2: 5,5-dimethyl-1,3-cyclohexadiene / 90 h / Reflux

With Acetyl bromide; In 5,5-dimethyl-1,3-cyclohexadiene; benzene;

DOI:10.1007/s00044-011-9891-y

Reference yield:

4-methyl-benzaldehyde (104-87-0) → di(p-tolyl)(dimethylaminoethoxy)methane hydrochloride (18483-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 144 h / Reflux

2: Acetyl bromide / benzene / 216 h / Reflux

3: 5,5-dimethyl-1,3-cyclohexadiene / 90 h / Reflux

With Acetyl bromide; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; benzene;

DOI:10.1007/s00044-011-9891-y

upstream raw materials:

4-methyl-benzaldehyde

para-methylphenylmagnesium bromide

2-(N,N-dimethylamino)ethanol

bromo(bis-p-tolyl)methane