3-CHLORO-4'-METHYLBENZHYDROL

Base Information

• Chemical Name: 3-CHLORO-4'-METHYLBENZHYDROL
• CAS No.: 13395-67-0
• Molecular Formula: C₁₄H₁₃ClO
• Molecular Weight: 232.71
• Mol file: 13395-67-0.mol

Synonyms:

Chemical Property of 3-CHLORO-4'-METHYLBENZHYDROL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-CHLORO-4'-METHYLBENZHYDROL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-4'-METHYLBENZHYDROL

There total 4 articles about 3-CHLORO-4'-METHYLBENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethylmagnesium bromide (925-90-6) + [3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-p-tolyl-methanol (135145-28-7,135145-29-8) → (3-chlorophenyl)(p-tolyl)methanol (135145-35-6,135145-36-7,13395-67-0) + (S)-1-(ethylsulfinyl)-4-methylbenzene (62961-00-6,1519-40-0,6378-07-0,67529-34-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jo00019a053

Reference yield: 90.0%

3-iodochlorobenzene (625-99-0) + 4-methyl-benzaldehyde (104-87-0) → (3-chlorophenyl)(p-tolyl)methanol (135145-35-6,135145-36-7,13395-67-0)

Guidance literature:

3-iodochlorobenzene; With TurboGrignard; In tetrahydrofuran; at 20 ℃;

4-methyl-benzaldehyde; In tetrahydrofuran; at 20 ℃; under 7757.43 Torr;

With ammonium chloride; In tetrahydrofuran; water;

DOI:10.1021/op200275d

Reference yield:

2-chlorophenylmagnesium bromide (36692-27-0) → (3-chlorophenyl)(p-tolyl)methanol (135145-35-6,135145-36-7,13395-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / diethyl ether / 0 °C

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

3: 93 percent / tetrahydrofuran / 0 °C

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00019a053

upstream raw materials:

ethylmagnesium bromide

[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-p-tolyl-methanol

2-chlorophenylmagnesium bromide

(R)-(+)-2-chlorophenyl 4-methylphenyl sulfoxide

Downstream raw materials:

3-Chlor-4'-methyl-benzhydrylchlorid