7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one

Base Information

Chemical Name:7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one
CAS No.:133999-06-1
Molecular Formula:C11H12ClNO
Molecular Weight:209.67200
Hs Code.:2933790090
DSSTox Substance ID:DTXSID40567647
Wikidata:Q82453599
Mol file:133999-06-1.mol

Synonyms:133999-06-1;7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one;7-CHLORO-4,4-DIMETHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;SCHEMBL6260606;DTXSID40567647;XOCSIBQQEXKLPV-UHFFFAOYSA-N;SB32907;BS-27182;7-Chloro-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one;7-chloro-4,4-dimethyl-3,4-dihyrdo-1H-quinolin-2-one

Suppliers and Price of 7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one
100mg
$ 45.00

J&W Pharmlab
7-Chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one 97%
500mg
$ 549.00

Chemenu
7-Chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one 95%
10g
$ 533.00

Chemenu
7-Chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one 95%
5g
$ 320.00

American Custom Chemicals Corporation
7-CHLORO-4,4-DIMETHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 95.00%
1G
$ 257.25

AK Scientific
7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one
5g
$ 531.00

Total 5 raw suppliers

Chemical Property of 7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one

Chemical Property:

PSA：32.59000
LogP:3.04490
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:209.0607417
Heavy Atom Count:14
Complexity:252

Purity/Quality:

97% ^*data from raw suppliers

7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC(=O)NC2=C1C=CC(=C2)Cl)C

Technology Process of 7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one

There total 3 articles about 7-Chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 91089-55-3
3-methyl-crotonic acid-(3-chloro-anilide)

: 133999-06-1
7-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With aluminum (III) chloride; In 1,2-dichloro-benzene; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.04.038

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 133999-06-1
7-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; triethylamine; In tetrahydrofuran; 1,2-dichloro-benzene; 2.1: |Friedel-Crafts Alkylation;
DOI:10.1016/j.bmcl.2013.04.038

Reference yield:

: 108-42-9
3-chloro-aniline

: 133999-06-1
7-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; triethylamine; In tetrahydrofuran; 1,2-dichloro-benzene; 2.1: |Friedel-Crafts Alkylation;
DOI:10.1016/j.bmcl.2013.04.038