3-(1H-BENZIMIDAZOL-2-YL)ANILINE

Base Information

• Chemical Name: 3-(1H-BENZIMIDAZOL-2-YL)ANILINE
• CAS No.: 7596-74-9
• Molecular Formula: C13H11N3
• Molecular Weight: 209.25
• Hs Code.: 2933290090
• Mol file: 7596-74-9.mol

Synonyms:3-(1H-benzo[d]imidazol-2-yl)benzenamine;3-(1H-BENZO[D]IMIDAZOL-2-YL)ANILINE;2-(m-aminophenyl)benzimidazole;3-(1H-1,3-benzodiazol-2-yl)aniline;1H-(benzimidazol-2-yl)-phenylamine;2-(3-Aminophenyl)benzimidazole;2-(3-aminophenyl)-1H-benzimidazole;3-(1H-Benzoimidazol-2-yl)-phenylamine;3-benzimidazol-2-ylphenylamine;

Chemical Property of 3-(1H-BENZIMIDAZOL-2-YL)ANILINE

Chemical Property:

• Vapor Pressure: 1.81E-09mmHg at 25°C
• Boiling Point: 482.5°C at 760 mmHg
• Flash Point: 277.3°C
• PSA: 54.70000
• Density: 1.286g/cm³
• LogP: 3.39330

Purity/Quality:

98%min ^*data from raw suppliers

3-(1H-Benzimidazol-2-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1H-BENZIMIDAZOL-2-YL)ANILINE

There total 16 articles about 3-(1H-BENZIMIDAZOL-2-YL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,2-diamino-benzene (95-54-5) + m-aminobenzaldehyde (1709-44-0,29159-23-7) → 3-(1H-benz[d]imidazol-2-yl)aniline (7596-74-9)

Guidance literature:

With sodium metabisulfite; In ethanol; water; at 74 ℃; for 0.15h; Wavelength; Irradiation; Sealed tube; Sonication; Green chemistry;

DOI:10.1002/jhet.3801

Reference yield: 92.0%

2-(3-nitrophenyl)-1H-benzimidazole (15456-62-9) → 3-(1H-benz[d]imidazol-2-yl)aniline (7596-74-9)

Guidance literature:

With stannous chloride hydrate; ethanol; at 88 ℃; for 1h;

Reference yield: 86.0%

meta-aminobenzoic acid (99-05-8,159139-79-4) + 1,2-diamino-benzene (95-54-5) → 3-(1H-benz[d]imidazol-2-yl)aniline (7596-74-9)

Guidance literature:

With polyphosphoric acid; at 160 ℃; for 3h;

DOI:10.3390/antibiotics10060728

upstream raw materials:

2-(3-nitrophenyl)-1H-benzimidazole

3-nitro-benzoic acid-(2-nitro-anilide)

meta-aminobenzoic acid

1,2-diamino-benzene

Downstream raw materials:

2-Methyl-3--6-bromo-quinazolin(3H)-4-one

2-Phenyl-3-quinazolin(3H)-4-one

2-Phenyl-3--6-iodo-q Quinazolin(3H)-4-one

2-Phenyl-3--6,8-dibromo-quinazolin(3H)-4-one

Refernces

• 1、 GURAV, SHAILESH S.,WAGHMODE, KRISHNAKANT T.,NIKAM, BANDOBA T.. "Efficient and facile synthesis of benzimidazole induced schiff bases and their potent antibacterial activity and computational study". . p. 1261 - 1266. Retrieved 2021/06/09.
• 2、 Abdelgawad, Mohamed A.,Ahmad, Waqas,Al-Muaikel, Nayef S.,Al-Sanea, Mohammad M.,Alanazi, Abdullah S.,Alharbi, Metab,Almalki, Atiah H.,Alzarea, Sami I.,Bakr, Rania B.,Bukhari, Syed N. A.,Ghoneim, Mohammed M.,Hegazy, Mostafa M.,Mostafa, Ehab M.,Mostafa-Hedeab, Gomaa,Musa, Arafa,Parambi, Della G. T.. "Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights". . p. 2325 - 2337. Retrieved 2022/01/13.