5-(Trifluoromethyl)pyrazin-2-OL

Base Information

• Chemical Name: 5-(Trifluoromethyl)pyrazin-2-OL
• CAS No.: 134510-03-5
• Molecular Formula: C₅H₃F₃N₂O
• Molecular Weight: 164.087
• European Community (EC) Number: 868-938-0
• Mol file: 134510-03-5.mol

Synonyms:134510-03-5;5-(TRIFLUOROMETHYL)PYRAZIN-2-OL;5-Trifluoromethyl-pyrazin-2-ol;5-(trifluoromethyl)-1H-pyrazin-2-one;5-(trifluoromethyl)pyrazin-2(1H)-one;5-HYDROXY-2-(TRIFLUOROMETHYL)PYRAZINE;2(1H)-Pyrazinone, 5-(trifluoromethyl)-;5-trifluoromethylpyrazin-2-one;SCHEMBL1931544;5-trifluoromethylpyrazine-2-one;SCHEMBL19707458;5-(Trifluoromethyl)pyrazin-2-one;QPNNXAAJWXPCDU-UHFFFAOYSA-N;MFCD13190191;MFCD23382443;2-Hydroxy-5-(trifluoromethyl)pyrazine;AKOS017344735;AKOS030529222;AB69940;CS-W004214;AS-47580;SY237344;DB-123758;F14428;EN300-6496107;Z1255495794

Chemical Property of 5-(Trifluoromethyl)pyrazin-2-OL

Chemical Property:

• PKA: 10.27±0.40(Predicted)
• PSA: 45.75000
• Density: 1.55±0.1 g/cm3(Predicted)
• LogP: 0.78870
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 164.01974721
• Heavy Atom Count: 11
• Complexity: 241

Purity/Quality:

97% ^*data from raw suppliers

5-(Trifluoromethyl)pyrazin-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(N=CC(=O)N1)C(F)(F)F

Technology Process of 5-(Trifluoromethyl)pyrazin-2-OL

There total 1 articles about 5-(Trifluoromethyl)pyrazin-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-trifluoromethyl-pyrazin-2-ylamine (69816-38-2) → 5-(trifluoromethyl)-pyrazin-2(1H)-one (134510-03-5)

Guidance literature:

Reference yield:

5-(trifluoromethyl)-pyrazin-2(1H)-one (134510-03-5) + 3-bromo-4-fluoro-5-cyano-trifluoromethylbenzene (133013-32-8) → 1-(2-cyano-4-trifluoromethyl-6-bromophenyl)-5-trifluoromethylpyrazin-2-one

Guidance literature:

In N-methyl-acetamide; hexane; ethyl acetate;

Reference yield:

5-(trifluoromethyl)-pyrazin-2(1H)-one (134510-03-5) + 5-Chloro-4-fluoro-3-nitro-trifluoromethylbenzene (101646-02-0) → 1-(2-nitro-4-trifluoromethyl-6-chlorophenyl)-5-trifluoromethylpyrazin-2-one

Guidance literature:

In N-methyl-acetamide; diethyl ether; Petroleum ether;

upstream raw materials:

5-trifluoromethyl-pyrazin-2-ylamine

Downstream raw materials:

2-chloro-5-(trifluoromethyl)-pyrazine