69816-38-2

Basic information

• Product Name: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE
• Synonyms: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE;5-(TRIFLUOROMETHYL)PYRAZIN-2-AMINE;5-TrifluoroMethyl-pyrazin-2-ylaMine;5-(Trifluoromethyl)pyrazine-2-amine;5-(trifluoromethyl)-2-Pyrazinamine
• CAS NO: 69816-38-2
• Molecular Formula: C₅H₄F₃N₃
• Molecular Weight: 163.1
• Mol File: 69816-38-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 226.204 °C at 760 mmHg
• Flash Point: 90.605 °C
• Appearance: /
• Density: 1.461 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.50±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE(69816-38-2)
• EPA Substance Registry System: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE(69816-38-2)

Safety Data

• Hazardous Substances Data: 69816-38-2(Hazardous Substances Data)

Usage

General Description

2-Amino-5-(trifluoromethyl)pyrazine is a chemical compound with the molecular formula C5H5F3N4. It is a heterocyclic organic compound that contains a pyrazine ring with an amino group and a trifluoromethyl group attached to it. 2-Amino-5-(trifluoromethyl)pyrazine is used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a flavor and fragrance ingredient in the production of food and cosmetics. 2-Amino-5-(trifluoromethyl)pyrazine is a white to light brown crystalline solid and has a melting point of 106-108°C. It is important to handle this compound with care as it may cause skin irritation and should be stored in a cool, dry place away from heat and sources of ignition.

Upstream product

• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 
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Downstream Products

• 1260667-12-6 2-amino-3-chloro-5-(trifluoromethyl)pyrazine 
• 1372197-49-3 6-(trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid 
• 1360055-12-4 6-tert-butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-6-oxo-5-(5-trifluoromethyl-pyrazin-2-ylamino)-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one 
• 1196152-38-1 2-bromo-5-(trifluoromethyl)-pyrazine 
• 1160608-05-8 [2-(2,6-Dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(5-trifluoromethyl-pyrazin-2-yl)-amine 
• 134510-03-5 5-(trifluoromethyl)-pyrazin-2(1H)-one 

Relevant articles and documents

CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-y which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.