Gomisin J

Base Information

Chemical Name:Gomisin J
CAS No.:66280-25-9
Molecular Formula:C22H28O6
Molecular Weight:388.461
Hs Code.:
UNII:X13A57600T
DSSTox Substance ID:DTXSID30216490
Nikkaji Number:J476.691A
Metabolomics Workbench ID:129544
ChEMBL ID:CHEMBL251864
Mol file:66280-25-9.mol

Synonyms:gomisin J

Suppliers and Price of Gomisin J

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Gomisin J
10mg
$ 490.00

Usbiological
Gomisin J
2mg
$ 602.00

TRC
GomisinJ
5mg
$ 605.00

DC Chemicals
GomisinJ >98%,StandardReferencesGrade
20 mg
$ 280.00

CSNpharm
GomisinJ
1mg
$ 82.00

CSNpharm
GomisinJ
5mg
$ 140.00

Crysdot
GomisinJ 95+%
5mg
$ 730.00

ChemScene
GomisinJ >99.0%
5mg
$ 150.00

ChemScene
GomisinJ >99.0%
1mg
$ 50.00

ChemScene
GomisinJ >99.0%
10mg
$ 250.00

Total 37 raw suppliers

Chemical Property of Gomisin J

Chemical Property:

Vapor Pressure:2.12E-14mmHg at 25°C
Melting Point:148-149℃
Boiling Point:587.5°Cat760mmHg
PKA:8.97±0.60(Predicted)
Flash Point:309.1°C
PSA：77.38000
Density:1.161g/cm³
LogP:4.17000
Storage Temp.:2-8°C
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:388.18858861
Heavy Atom Count:28
Complexity:457

Purity/Quality:

≥98% ^*data from raw suppliers

Gomisin J ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)O)OC)OC)OC)OC)O
Isomeric SMILES:C[C@@H]1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C[C@@H]1C)O)OC)OC)OC)OC)O
Uses Gomisin J is a promising drug for anti-ovarian cancer utilization. Also, it exhibits strong inhibition towards the glucuronidation of SN-8.

Technology Process of Gomisin J

There total 9 articles about Gomisin J which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (6S,7R,S-Biar)-3,10-dibenzyloxy-5,6,7,8-tetrahydro-6,7-dimethyl-1,2,11,12-tetramethoxydibenzocyclooctene

: 66280-25-9
(-)-gomisin J

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; Ambient temperature;
DOI:10.1016/0040-4020(95)00701-9

Reference yield: 95.0%

: (6S,7R,S-Biar)-5,6,7,8-tetrahydro-3,10-dihydroxy-6,7-dimethyl-1,2,11,12-tetramethoxydibenzocyclooctene-4,9-dicarbaldehyde

: 66280-25-9
(-)-gomisin J

Guidance literature:: With propylene glycol; toluene-4-sulfonic acid; In toluene; for 1.5h; Heating;
DOI:10.1016/0040-4020(95)00701-9

Reference yield:

: 61281-38-7,63598-55-0,63640-13-1,69176-53-0,101757-58-8,114488-89-0,115587-63-8,115587-64-9
(-)-deoxyschizandrin

: 66280-25-9
(-)-gomisin J

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / trifluoroacetic acid / 24 h / Heating

2: 100 percent / BCl₃ / CH₂Cl₂ / 18 h / 0 °C

3: 84 percent / K₂CO₃ / dimethylformamide / 5 h / 70 °C

4: 87 percent / Rh(PPh₃)3Cl / toluene / 48 h / Heating

5: 100 percent / hydrogen / 10percent Pd-C / ethyl acetate / 2 h / Ambient temperature

With Wilkinson's catalyst; hydrogen; boron trichloride; potassium carbonate; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1016/0040-4020(95)00701-9