Deoxyschizandrin

Base Information

Chemical Name:Deoxyschizandrin
CAS No.:61281-38-7
Molecular Formula:C₂₄H₃₂O₆
Molecular Weight:416.514
Hs Code.:29093090
DSSTox Substance ID:DTXSID20976773
Nikkaji Number:J527.345E
Wikipedia:Deoxyschizandrin
Wikidata:Q27149861
Metabolomics Workbench ID:137956
ChEMBL ID:CHEMBL479898
Mol file:61281-38-7.mol

Synonyms:deoxyschisandrin;deoxyschizandrin;schisandrin A;schizandrin A

Suppliers and Price of Deoxyschizandrin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SchizandrinA
50mg
$ 230.00

TRC
SchizandrinA
250mg
$ 400.00

TCI Chemical
Schisandrin A
100MG
$ 447.00

TCI Chemical
Schisandrin A
25MG
$ 163.00

Sigma-Aldrich
Schisandrin A ≥98% (HPLC)
10mg
$ 91.80

Sigma-Aldrich
Schisandrin A ≥98% (HPLC)
50mg
$ 373.00

Sigma-Aldrich
Schisandrin A analytical standard
50mg
$ 343.00

Medical Isotopes, Inc.
SchizandrinA
10 mg
$ 190.00

Labseeker
Schisandrin A 95
1g
$ 1283.00

JR MediChem
Schizandrin?A?(NewProduct) 98%
100mg
$ 108.00

Total 94 raw suppliers

Chemical Property of Deoxyschizandrin

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:2.39E-11mmHg at 25°C
Melting Point:116-117 °C
Refractive Index:1.519
Boiling Point:544.2 °C at 760 mmHg
Flash Point:215.6 °C
PSA：55.38000
Density:1.08 g/cm³
LogP:4.28400
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:416.21988874
Heavy Atom Count:30
Complexity:484

Purity/Quality:

99%, ^*data from raw suppliers

SchizandrinA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)OC)OC)OC
Description Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC50 = 3.2 μM). Schisandrin A (10, 20, and 50 μM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 μM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; ) in a mouse model of Alzheimer’s disease.
Uses Schizandrin A is an extract from Schisandra chinesis. a dibenzocyclooctadiene lignan with antiinflammatory activity.

Technology Process of Deoxyschizandrin

There total 46 articles about Deoxyschizandrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 50544-08-6,72730-20-2,75597-96-5,115587-61-6,107191-91-3
5,5'-(2,3-dimethylbutane-1,4-diyl)bis(1,2,3-trimethoxybenzene)

: 61281-38-7,63598-55-0,63640-13-1,69176-53-0,101757-58-8,114488-89-0,115587-63-8,115587-64-9,157087-43-9,157087-44-0
(+/-)-deoxyschizandrin

Guidance literature:: With vanadium(V) oxytrifluoride; trifluoroacetic acid; In dichloromethane; 1) -78 deg C, 30 min, 2) room temperature, 30 min;

Reference yield: 56.0%

: 50544-08-6,72730-20-2,75597-96-5,115587-61-6,107191-91-3
5,5'-(2,3-dimethylbutane-1,4-diyl)bis(1,2,3-trimethoxybenzene)

: 61281-38-7,63598-55-0,63640-13-1,69176-53-0,101757-58-8,114488-89-0,115587-63-8,115587-64-9,157087-43-9,157087-44-0
(+/-)-deoxyschizandrin

Guidance literature:: With vanadium(V) oxytrifluoride; trifluoroacetic acid; In dichloromethane; 1) -78 deg C, 30 min, 2) room temperature, 30 min;

Reference yield:

: 487-11-6
elemicin

: 61281-38-7,63598-55-0,63640-13-1,69176-53-0,101757-58-8,114488-89-0,115587-63-8,115587-64-9,157087-43-9,157087-44-0
(+/-)-deoxyschizandrin

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / HBr / acetic acid / 3 h / 0 °C

2: 1) Mg, 2) (E)-2-t-butyl-3-phenyloxaziridine / 1) THF, 0 deg C, 2) 0 deg C, 15 h

3: 56 percent / trifluoroacetic acid, VOF₃ / CH₂Cl₂ / 1) -78 deg C, 30 min, 2) room temperature, 30 min

With 2-tert-butyl-3-phenyloxaziridine; vanadium(V) oxytrifluoride; hydrogen bromide; magnesium; trifluoroacetic acid; In dichloromethane; acetic acid;