Propanedioic acid, [3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)-

Base Information

Chemical Name:Propanedioic acid, [3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)-
CAS No.:134935-91-4
Molecular Formula:C33H41N3O9
Molecular Weight:623.703
Hs Code.:

Propanedioic acid,
[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb
onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)-

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Technology Process of Propanedioic acid, [3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)-

There total 5 articles about Propanedioic acid, [3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-6-[[(phenylmethoxy)carb onyl]amino]hexyl](1H-indol-3-ylmethyl)-, dimethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 87-52-5
3-(Dimethylaminomethyl)indole

: 134935-89-0
Methyl 8-benzyloxycarbonylamino-5(S)-tert-butyloxycarbonylamino-2-methoxycarbonyl-4-oxooctanoate

: 134935-91-4
Methyl 8-benzyloxycarbonylamino-5(S)-tert-butyloxycarbonylamino-2-(indole-3-yl)methyl-2-methoxycarbonyl-4-oxooctanoate

Guidance literature:: With sodium methylate; methyl iodide; In methanol; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(01)90127-9

Reference yield: 76.0%

: 6000-64-2
methiodide of gramine

: 134935-89-0
2-(6-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-oxo-hexyl)-malonic acid dimethyl ester

: 134935-91-4
2-(6-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-oxo-hexyl)-2-(1H-indol-3-ylmethyl)-malonic acid dimethyl ester

Guidance literature:: With sodium methylate;
DOI:10.1016/S0040-4039(00)74495-9

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 134935-91-4
Methyl 8-benzyloxycarbonylamino-5(S)-tert-butyloxycarbonylamino-2-(indole-3-yl)methyl-2-methoxycarbonyl-4-oxooctanoate

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) NaI / 1.) 1,2-dimethoxyethane, rt, 15 min, 2.) rt, 1 h

3: 76 percent / sodium methoxide, methyl iodide / methanol / 1 h / 0 °C

With sodium methylate; sodium iodide; methyl iodide; In methanol;
DOI:10.1016/S0040-4020(01)90127-9