Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine

Base Information

Chemical Name:Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine
CAS No.:135007-71-5
Molecular Formula:C₂₇H₃₀N₂
Molecular Weight:382.549
Hs Code.:
ChEMBL ID:CHEMBL357717
DSSTox Substance ID:DTXSID901342349
Nikkaji Number:J493.673F
Mol file:135007-71-5.mol

Synonyms:CHEMBL357717;SCHEMBL9321845;DTXSID901342349;BDBM50280470;Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine;135007-71-5;rel-(2R,3R)-2-(Diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine

Suppliers and Price of Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine

Chemical Property:

XLogP3:5.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:382.240898965
Heavy Atom Count:29
Complexity:461

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2CCC1C(C2C(C3=CC=CC=C3)C4=CC=CC=C4)NCC5=CC=CC=C5
Isomeric SMILES:C1CN2CCC1[C@H]([C@H]2C(C3=CC=CC=C3)C4=CC=CC=C4)NCC5=CC=CC=C5

Technology Process of Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine

There total 5 articles about Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 32531-66-1
3-keto-2-benzhydrylquinuclidine

: 100-46-9
benzylamine

: 32531-17-2,32531-18-3,135007-71-5
cis-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine

Guidance literature:: 3-keto-2-benzhydrylquinuclidine; benzylamine; With (R)-10-camphorsulfonic acid; In water; toluene; Reflux; Large scale;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; toluene; at 20 - 30 ℃; for 24h; Large scale;

Reference yield:

: 24123-89-5
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one

: 32531-17-2,32531-18-3,135007-71-5
cis-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Large scale

1.2: 3 h / 5 - 10 °C / Large scale

2.1: (R)-10-camphorsulfonic acid / toluene; water / Reflux; Large scale

2.2: 24 h / 20 - 30 °C / Large scale

With copper(I) bromide dimethylsulfide complex; (R)-10-camphorsulfonic acid; In tetrahydrofuran; water; toluene;

Reference yield:

: 100-52-7
benzaldehyde

: 32531-17-2,32531-18-3,135007-71-5
cis-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / Reflux; Large scale

2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Large scale

2.2: 3 h / 5 - 10 °C / Large scale

3.1: (R)-10-camphorsulfonic acid / toluene; water / Reflux; Large scale

3.2: 24 h / 20 - 30 °C / Large scale

With copper(I) bromide dimethylsulfide complex; (R)-10-camphorsulfonic acid; water; sodium hydroxide; In tetrahydrofuran; water; toluene;