6-Methyl-2-(phthalimido)pyridine

Base Information

• Chemical Name: 6-Methyl-2-(phthalimido)pyridine
• CAS No.: 36932-61-3
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• DSSTox Substance ID: DTXSID60351141
• Wikidata: Q82127315
• ChEMBL ID: CHEMBL1443997
• Mol file: 36932-61-3.mol

Synonyms:36932-61-3;2-(6-methylpyridin-2-yl)isoindoline-1,3-dione;6-Methyl-2-(phthalimido)pyridine;2-(6-methylpyridin-2-yl)isoindole-1,3-dione;2-(6-methylpyridin-2-yl)-1H-isoindole-1,3(2H)-dione;2-(6-methylpyridin-2-yl)-2,3-dihydro-1H-isoindole-1,3-dione;CBMicro_004909;Oprea1_343423;MLS001202188;SCHEMBL5026395;CHEMBL1443997;DTXSID60351141;CFNKFWRAPXKASS-UHFFFAOYSA-N;HMS2883H16;AMY42534;SMSF0003537;MFCD00444985;N-(2-methylpyridin-6-yl)phthalimide;STK756074;AKOS001722659;CB06897;SMR000565043;BIM-0005013.P001;A51206;A903209;SR-01000516571;SR-01000516571-1

Chemical Property of 6-Methyl-2-(phthalimido)pyridine

Chemical Property:

• Boiling Point: 433.6±47.0 °C(Predicted)
• PKA: 4.06±0.19(Predicted)
• PSA: 50.27000
• Density: 1.351±0.06 g/cm3(Predicted)
• LogP: 2.25560
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 238.074227566
• Heavy Atom Count: 18
• Complexity: 345

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of 6-Methyl-2-(phthalimido)pyridine

There total 1 articles about 6-Methyl-2-(phthalimido)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Amino-6-methylpyridine (1824-81-3) + phthalic anhydride (85-44-9) → 6-methyl-2-(phthalimido)pyridine (36932-61-3)

Guidance literature:

at 190 ℃; for 2h; Inert atmosphere;

Reference yield: 62.0%

6-methyl-2-(phthalimido)pyridine (36932-61-3) → 2-(6-bromomethylpyridin-2-yl)isoindole-1,3-dione (83592-42-1)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; water;

DOI:10.1002/jhet.5570380125

Reference yield: 46.7%

6-methyl-2-(phthalimido)pyridine (36932-61-3) → 2-(6-bromomethylpyridin-2-yl)isoindole-1,3-dione (83592-42-1) + 2-(6-dibromomethyl-pyridin-2-yl)-isoindole-1,3-dione

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide; for 5h; Reflux; Inert atmosphere;

DOI:10.1002/ddr.21585

upstream raw materials:

2-Amino-6-methylpyridine

phthalic anhydride

Downstream raw materials:

2-(6-bromomethylpyridin-2-yl)isoindole-1,3-dione

2-(6-phenethylpyridin-2-yl)isoindole-1,3-dione

2-amino-6-(2-phenylethyl)pyridine

(6-Amino-pyridin-2-yl)-methanol