Technology Process of Pyridine, 1,2,3,6-tetrahydro-5-methyl-4-phenyl-
There total 4 articles about Pyridine, 1,2,3,6-tetrahydro-5-methyl-4-phenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyl-5-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine;
With
chloroformic acid ethyl ester;
In
1,2-dichloro-ethane;
at 0 ℃;
for 5h;
Heating / reflux;
In
methanol;
for 2h;
Heating / reflux;
With
sodium hydroxide;
In
methanol; water;
pH=9;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphoric acid; phosphorus pentoxide / 5 h / 100 °C
2.1: chloroformic acid ethyl ester / 1,2-dichloro-ethane / 5 h / 0 °C / Heating / reflux
2.2: 2 h / Heating / reflux
2.3: pH 9
With
phosphoric acid; phosphorus pentoxide; chloroformic acid ethyl ester;
In
1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diethyl ether / 2 h / -78 °C
2.1: phosphoric acid; phosphorus pentoxide / 5 h / 100 °C
3.1: chloroformic acid ethyl ester / 1,2-dichloro-ethane / 5 h / 0 °C / Heating / reflux
3.2: 2 h / Heating / reflux
3.3: pH 9
With
phosphoric acid; phosphorus pentoxide; chloroformic acid ethyl ester;
In
diethyl ether; 1,2-dichloro-ethane;
