2-(4-METHOXY-PHENYL)-INDOLIZINE

Base Information

• Chemical Name: 2-(4-METHOXY-PHENYL)-INDOLIZINE
• CAS No.: 7496-82-4
• Molecular Formula: C15H13 N O
• Molecular Weight: 223.274
• Hs Code.: 2933990090
• Mol file: 7496-82-4.mol

Synonyms:Indolizine,2-(p-methoxyphenyl)- (7CI); 2-(4-Methoxyphenyl)indolizine;2-(4-Methoxyphenyl)pyrrolo[1,2-a]pyridine; NSC 405331

Chemical Property of 2-(4-METHOXY-PHENYL)-INDOLIZINE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 13.64000
• Density: 1.08g/cm³
• LogP: 3.61490

Purity/Quality:

99.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHOXY-PHENYL)-INDOLIZINE

There total 9 articles about 2-(4-METHOXY-PHENYL)-INDOLIZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

α-picoline (109-06-8) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-methoxyphenyl)-indolizine (7496-82-4)

Guidance literature:

α-picoline; 2-Bromo-4'-methoxyacetophenone; In acetone; for 1h; Heating;

With potassium carbonate; for 5h;

DOI:10.1016/S0960-894X(03)00299-3

Reference yield: 75.0%

p-methoxyphenacyl-α-picolinium bromide → 2-(4-methoxyphenyl)-indolizine (7496-82-4)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.166667h; Heating;

Reference yield: 68.0%

p-methoxyphenacyl-α-picolinium bromide + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 3-(4-methoxybenzoyl)indolizine + 2-(4-methoxyphenyl)-indolizine (7496-82-4)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.10.052

upstream raw materials:

α-picoline

2-Bromo-4'-methoxyacetophenone

p-methoxyphenacyl-α-picolinium iodide

N,N-dimethylformamide di-tert-butyl acetal

Downstream raw materials:

(3,5-Dibromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

2-(4-hydroxyphenyl)indolizine

2-(4-methoxyphenyl)octahydroindolizine

(3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

Refernces

• 1、 Cao, Hua,Lin, Jiatong,Liu, Xiang,Song, Dan,Zhan, Haiying,Zhang, Zemin,Zhuang, Canzhan. "Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions". supporting information. p. 5284 - 5288. Retrieved 2021/06/28.
• 2、 Gomes, Caroline S.,Lenard?o, Eder J.,Monzon, Loana I.,Penteado, Filipe,Perin, Gelson,Silveira, Claudio C.. "Photocatalytic Synthesis of 3-Sulfanyl- and 1,3-Bis(sulfanyl)indolizines Mediated by Visible Light". supporting information. . Retrieved 2020/04/07.