(3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

Base Information

• Chemical Name: (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone
• CAS No.: 345941-11-9
• Molecular Formula: C₂₂H₁₆BrNO₃
• Molecular Weight: 422.278
• Mol file: 345941-11-9.mol

Synonyms:(3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

Chemical Property of (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone

There total 3 articles about (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Toluene-4-sulfonic acid 2-bromo-4-[2-(4-methoxy-phenyl)-indolizine-3-carbonyl]-phenyl ester (88273-79-4) → (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone (345941-11-9)

Guidance literature:

With sodium hydroxide; In methanol; for 20h; Heating;

Reference yield:

2-(4-methoxyphenyl)-indolizine (7496-82-4) → (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone (345941-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 20 h / 20 - 50 °C

2: 30 percent sodium hydroxyde / methanol / 20 h / Heating

With sodium hydroxide; In methanol; 1,2-dichloro-ethane;

Reference yield:

chlorure de (bromo-3 tosyloxy)-4 benzoyle (77823-21-3) → (3-Bromo-4-hydroxy-phenyl)-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone (345941-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 20 h / 20 - 50 °C

2: 30 percent sodium hydroxyde / methanol / 20 h / Heating

With sodium hydroxide; In methanol; 1,2-dichloro-ethane;

upstream raw materials:

Toluene-4-sulfonic acid 2-bromo-4-[2-(4-methoxy-phenyl)-indolizine-3-carbonyl]-phenyl ester

2-(4-methoxyphenyl)-indolizine

chlorure de (bromo-3 tosyloxy)-4 benzoyle

Downstream raw materials:

[3-Bromo-4-(3-dibutylamino-propoxy)-phenyl]-[2-(4-methoxy-phenyl)-indolizin-3-yl]-methanone; compound with oxalic acid