3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine

Base Information

Chemical Name:3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine
CAS No.:19725-24-7
Molecular Formula:C19H23 N O
Molecular Weight:281.39
Hs Code.:
Mol file:19725-24-7.mol

Synonyms:Phenol,m-(1-phenethyl-3-piperidyl)- (8CI); 3-(3-Hydroxyphenyl)-N-phenethylpiperidine

Suppliers and Price of 3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine

Chemical Property:

Vapor Pressure:4.31E-08mmHg at 25°C
Melting Point:131 °C
Boiling Point:432.6°Cat760mmHg
PKA:9.95±0.10(Predicted)
Flash Point:212.1°C
PSA：23.47000
Density:1.088g/cm³
LogP:3.75220

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine

There total 14 articles about 3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 344244-24-2
3-(3-benzyloxyphenyl)-1-phenethylpiperidine

: 19725-24-7
3-(3-hydroxyphenyl)-N-phenethylpiperidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid;
DOI:10.1002/recl.19811000909

Reference yield: 42.0%

: 146798-12-1
N-phenethyl-3-(3-methoxyphenyl)piperidine

: 19725-24-7
3-(3-hydroxyphenyl)-N-phenethylpiperidine

Guidance literature:: With hydrogen bromide; at 120 ℃; for 2h;
DOI:10.1021/jm00144a021

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 19725-24-7
3-(3-hydroxyphenyl)-N-phenethylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature

2: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

3: 1.) NaBH₄ / 1.) benzene, T<15 deg C, 2 h, 2.) benzene, reflux, 3 h

4: 42 percent / 48percent aq. HBr / 2 h / 120 °C

With hydrogenchloride; sodium tetrahydroborate; bis(triphenylphosphine)nickel(II) chloride; hydrogen bromide; hydrogen; platinum(IV) oxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00144a021