Technology Process of 3-(3-benzyloxyphenyl)-1-phenethylpiperidine
There total 8 articles about 3-(3-benzyloxyphenyl)-1-phenethylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium diisopropylamide / tetrahydrofuran
2: 25percent sulfuric acid, 8N chromic acid / acetone
3: KOH / ethanol; H2O / 6 h / Heating
4: 74 percent / acetic anhydride / 3 h / Heating
5: 2.) acetic anhydride / 1.) benzene, 1 h, reflux; 2.) 5 h, reflux
6: 92 percent / boron tribromide / CH2Cl2 / 2 h / Ambient temperature
7: 85 percent / potassium carbonate / dimethylformamide
8: 76 percent / LiAlH4 / tetrahydrofuran / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; acetic anhydride; boron tribromide; chromic acid; potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/recl.19811000909
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 74 percent / acetic anhydride / 3 h / Heating
2: 2.) acetic anhydride / 1.) benzene, 1 h, reflux; 2.) 5 h, reflux
3: 92 percent / boron tribromide / CH2Cl2 / 2 h / Ambient temperature
4: 85 percent / potassium carbonate / dimethylformamide
5: 76 percent / LiAlH4 / tetrahydrofuran / Heating
With
lithium aluminium tetrahydride; acetic anhydride; boron tribromide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/recl.19811000909
