2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

Base Information

• Chemical Name: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide
• CAS No.: 136604-50-7
• Molecular Formula: C13H11N3O2S.BrH
• Molecular Weight: 354.227
• Hs Code.: 2934100090
• Mol file: 136604-50-7.mol

Synonyms:2-Amino-5-(2-nitro-phenyl)-<1.3.4>thiadiazol;1,3,4-Thiadiazol-2-amine,5-(2-nitrophenyl);2-amino-5-(2-phtalimidoethyl)thiazole hydrobromide;2-amino-5-(2-phthalimidoethyl)thiazole hydrobromide;2-amino-5-(2-nitrophenyl)-1,3,4-thiadiazole;5-(2-nitro-phenyl)-[1,3,4]thiadiazol-2-ylamine;5-(2-Nitro-phenyl)-[1,3,4]thiadiazol-2-ylamin;2-amino-5-o-nitrophenyl-1,3,4-thiadiazole;

Chemical Property of 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

Chemical Property:

• PSA: 105.26000
• LogP: 2.39010

Purity/Quality:

99%, ^*data from raw suppliers

2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

There total 7 articles about 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-bromo-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyraldehyde (133118-36-2) + thiourea (17356-08-0) → 2-amino-5-(2-phthalimidoethyl)thiazole hydrobromide (136604-50-7)

Guidance literature:

In acetone; at 20 ℃;

Reference yield:

phthalic anhydride (85-44-9) → 2-amino-5-(2-phthalimidoethyl)thiazole hydrobromide (136604-50-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 3 h / 140 °C

2: oxalyl chloride, DMSO, / CH₂Cl₂ / 30 h / -50 °C

3: Br₂ / CCl₄ / 3 h / Ambient temperature

4: dimethylformamide / 3 h / 120 °C

With oxalyl dichloride; bromine; dimethyl sulfoxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00095a021

Reference yield:

4-phthalimidobutanal (3598-60-5) → 2-amino-5-(2-phthalimidoethyl)thiazole hydrobromide (136604-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / CCl₄ / Ambient temperature

2: acetone / Ambient temperature

With bromine; In tetrachloromethane; acetone;

DOI:10.1021/jm990012z

upstream raw materials:

2-bromo-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyraldehyde

thiourea

4-phthalimidobutanal

potassium phtalimide

Downstream raw materials:

N-2-<(2-amino-5-thiazolyl)ethyl>-3,4,5-trimethoxyphenethylamine

N-2-<(2-amino-5-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide