3598-60-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(Phthalimidyl)butanal is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a building block in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, 4-(Phthalimidyl)butanal is utilized as a crucial intermediate in the production of different types of dyes. Its chemical properties make it suitable for creating a wide range of colorants used in various applications.
Used in Agricultural Chemicals Industry:
4-(Phthalimidyl)butanal is also employed as an intermediate in the synthesis of agricultural chemicals. Its role in this industry is vital for the development of effective products that contribute to enhanced crop protection and yield.
It is important to handle 4-(Phthalimidyl)butanal with care due to its potential health hazards. It should be used in a well-ventilated area and with the appropriate personal protective equipment to ensure safety during research, development, and production processes.

InChI:InChI=1/C12H11NO3/c14-8-4-3-7-13-11(15)9-5-1-2-6-10(9)12(13)16/h1-2,5-6,8H,3-4,7H2

Upstream product

• 10314-06-4 4-phthalimidobutyryl chloride 
• 85-44-9 phthalic anhydride 
• 83179-86-6 2-(buta-2,3-dien-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione 
• 100-51-6 benzyl alcohol 

Downstream Products

• 149194-43-4 diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate 
• 146548-65-4 [1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester 
• 94830-02-1 2-{4-[(4-Chloro-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94830-01-0 2-{4-[(2-Methoxy-4-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94830-00-9 2-{4-[(4-Methoxy-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 133787-02-7 α-N-benzoyl-δ-N-phthaloylornithine 
• 74510-03-5 1,3-Diphenyl-7-phthalimido-1,4-heptandion 
• 95711-01-6 [1-(Benzhydryl-amino)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphinic acid 
• 74510-02-4 1-Phenyl-7-phthalimido-1,4-heptandion 
• 20820-73-9 1,4-diaminobutylphosphonic acid 
• 901773-73-7 [4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-formylamino-butyl]-phosphonic acid diphenyl ester 
• 558444-72-7 (S)-2-[4-(5,6,7,8-tetrahydro-quinolin-8-ylamino)-butyl]-isoindole-1,3-dione 
• 15741-71-6 N-phthalimidotryptamine 
• 115338-32-4 NAN-190 

Relevant academic research and scientific papers

Precious metal complexes of bis(pyridyl)allenes: Synthesis and catalytic and medicinal applications

The incorporation of donor-type substituents on the allene core opens up the possibility of coordination complexes in which the metal is bonded to the donor groups, with or without interaction with the double bond system. Despite the challenges in the syn

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

A THERANOSTIC PROBE AND ITS USE FOR TARGETING AND/OR LABELING THE EGFR KINASE AND/OR THE CELLS EXPRESSING EGFR OR ITS FAMILY MEMBERS

The present application is directed to a theranostic probe and its use for targeting and/or labeling the EGFR kinase and/or the cells expressing EGFR or its family members.

Exploring endoperoxides as a new entry for the synthesis of branched azasugars

A new class of nitrogen-containing endoperoxides were synthesised by a photochemical [4 + 2]-cycloaddition between a diene and singlet oxygen. The endoperoxides were dihydroxylated and protected to provide a series of endoperoxide building blocks for organic synthesis, with potential use as precursors for the synthesis of branched azasugars. Preliminary exploration of the chemistry of these building blocks provided access to a variety of derivatives including tetrahydrofurans, epoxides and protected amino-tetraols.

Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile

The reaction of isocyanomethylenetriphenylphosphorane, generated in situ from the corresponding phosphonium salt, with a diverse set of aldehydes afforded vinyl isocyanides in good to high yields. Excellent E-selectivity was observed for aliphatic aldehydes and 2,6-disubstituted aromatic aldehydes, whereas Z-olefins were formed predominantly with ortho-substituted aryl aldehydes. (Z)-1-Bromo-2-(2-isocyanovinyl)benzene (5l) was found to be a truly universal isonitrile since, after Ugi reaction, the resulting secondary amide unit (RNHCO-) is convertible under both acidic and basic conditions. The application of 5l in the synthesis of polyheterocycles is also illustrated.

Compounds and methods for protease detection

Alternative methods for the detection and measurement of proteases in biological samples and compounds which allow for such detection are required to allow for rapid and selective identification of these enzymes. Compounds which allow for selective identification of these enzymes are provided with assays and kits for their use.

Enantioselective NHC-Catalyzed Redox [4 + 2]-Hetero-Diels-Alder Reactions Using α,β-Unsaturated Trichloromethyl Ketones as Amide Equivalents

α,β-Unsaturated trichloromethyl ketones are suitable α,β-unsaturated amide and ester equivalents in N-heterocyclic carbene (NHC)-catalyzed redox hetero-Diels-Alder reactions with azolium enolates generated from α-aroyloxyaldehydes. The initially formed syn-dihydropyranone products can be isolated or can undergo ring-opening with benzylamine followed by aminolysis of the resulting CCl3 ketone to form a range of diamides with high diastereo- and enantioselectivity (up to >95:5 dr and >99% ee).

Synthesis of phosphorus isosters of β-amyloid peptides fragments

We have developed a synthetic route to pseudo dipeptides, analogs of certain fragments of β-amyloid peptides (products of the APP protein hydrolysis). These compounds can be used for preparation of phosphinic acidic oligopeptides representing the peptide sequence of the β-amyloid but containing the phosphorus isoster peptide fragment. Synthesis of pseudo ornityl-glutamate, pseudo arginyl-glutamate, pseudo glycyl-leucine, and pseudo isoleucyl-glycine via amino- and amidoalkylation of phosphonic acids containing the structural isoster of the corresponding amino acid is described.

AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary metal complex, or a stereochemically isomeric form thereof; (formula I) compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.

MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF

Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.