4-NITROSOPHENOL

Base Information

• Chemical Name: 4-NITROSOPHENOL
• CAS No.: 637-62-7
• Molecular Formula: C6H5NO2
• Molecular Weight: 123.111
• Hs Code.: 2928000090
• Mol file: 637-62-7.mol

Synonyms:2,5-Cyclohexadiene-1,4-dione,monooxime (9CI);p-Benzoquinone, monooxime (6CI,7CI,8CI);1,4-Benzoquinone4-oxime;NSC 239647;Quinone 4-oxime;Quinone monooxime;p-Benzoquinone4-oxime;p-Benzoquinone monoxime;p-Benzoquinone oxime;p-Quinone monooxime;p-Quinone monoxime;

Chemical Property of 4-NITROSOPHENOL

Chemical Property:

• Melting Point: 216 °C
• Boiling Point: 265.9 °C at 760 mmHg
• PKA: 6.13±0.10(Predicted)
• Flash Point: 114.6 °C
• PSA: 49.66000
• Density: 1.23 g/cm³
• LogP: 0.51170
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-BenzoquinoneMonoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Benzoquinone MonoxiMe is a reagent used to prepare poly-substituted benzenes.

Technology Process of 4-NITROSOPHENOL

There total 34 articles about 4-NITROSOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

hydroquinone (123-31-9,8027-02-9) → p-benzoquinone oxime (637-62-7)

Guidance literature:

hydroquinone; With 3,6-bis(triphenylphosphonium)cyclohexene dichromate; at 20 ℃; for 0.0833333h;

With hydroxylamine; for 0.2h;

DOI:10.1080/10426500601015724

Reference yield: 88.0%

phenol (108-95-2,27073-41-2) → p-benzoquinone oxime (637-62-7)

Guidance literature:

With i-AmNO₂; potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jo951873s

Reference yield: 55.0%

copper(II) bis(4-nitrosophenolato)di(nitroso) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + p-benzoquinone oxime (637-62-7)

Guidance literature:

With polymer-supported thiourea; In acetone; at 20 ℃; for 24h; Molecular sieve; Inert atmosphere;

DOI:10.3390/molecules24224154

upstream raw materials:

ethanol

4-(phenylaminocarbonyloxyimino)cyclohexa-2,5-dien-1-one

4-methoxynitrosobenzene

4-nitroso-N-methylaniline

Downstream raw materials:

4,4'-dihydroxyazoxybenzene

[1]naphthyl-acetic acid-(4-hydroxyimino-cyclohexa-2,5-dienylidenehydrazide)

[1,4]benzoquinone oxime-semicarbazone

azophenin

Refernces

• 1、 -. "Preparation method of P-benzoquinone dioxime". Paragraph 0061-0070; 0078-0087; 0095-0104. . Retrieved 2021/12/07.
• 2、 Nicholls, Alexander J.,Batsanov, Andrei S.,Baxendale, Ian R.. "Copper-mediated nitrosation: 2-nitrosophenolato complexes and their use in the synthesis of heterocycles". . . Retrieved 2019/11/28.