Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl-

Base Information

Chemical Name:Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl-
CAS No.:137054-47-8
Molecular Formula:C₂₈H₃₁ClN₂O₅
Molecular Weight:511.018
Hs Code.:
Mol file:137054-47-8.mol

Synonyms:

Suppliers and Price of Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl-

Chemical Property:

Purity/Quality:

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Technology Process of Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl-

There total 5 articles about Piperazine, 1-[2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52009-53-7
2-chloro-3,4-dimethoxy-benzoic acid

: 137054-47-8
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

4.1: Inert atmosphere

With boron tribromide; potassium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014

Reference yield:

: 5417-17-4
2-chloro-3,4-dimethoxybenzaldehyde

: 137054-47-8
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: aminosulfonic acid; sodium chlorite / 1,4-dioxane; water / 0.5 h / 0 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

5.1: Inert atmosphere

With sodium chlorite; aminosulfonic acid; boron tribromide; potassium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014

Reference yield:

: 1338705-74-0
C₂₄H₂₃ClO₆

: 137054-47-8
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

2: Inert atmosphere

With sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2018.06.014