CID 14988714

Base Information

Chemical Name:CID 14988714
CAS No.:137103-59-4
Molecular Formula:C22H18FN3O
Molecular Weight:359.403
Hs Code.:
ChEMBL ID:CHEMBL105787
DSSTox Substance ID:DTXSID601025388
Nikkaji Number:J491.820G

Synonyms:137103-59-4;CHEMBL105787;SCHEMBL9202374;DTXSID601025388;1-(4-fluorophenyl)-2-imidazol-1-yl-1-(3-pyridin-4-ylphenyl)ethanol

Suppliers and Price of CID 14988714

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of CID 14988714

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:359.14339037
Heavy Atom Count:27
Complexity:465

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(CN2C=CN=C2)(C3=CC=C(C=C3)F)O)C4=CC=NC=C4

Technology Process of CID 14988714

There total 4 articles about CID 14988714 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 59020-06-3
4-trimethylstannyl-pyridine

: 142657-43-0
1-(3-Bromo-phenyl)-1-(4-fluoro-phenyl)-2-imidazol-1-yl-ethanol

: 137103-59-4
1-(4-fluorophenyl)-1-[3-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/jm00095a009

Reference yield:

: 2592-86-1
(m-Bromophenyl)lithium

: 137103-59-4
1-(4-fluorophenyl)-1-[3-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 °C

2: 30 percent / t-BuOK / dimethylformamide / 90 °C

3: 23 percent / Et₃N, Pd(PPh₃)2Cl₂ / dimethylformamide / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a009

Reference yield:

: 2-(3-Bromo-phenyl)-2-(4-fluoro-phenyl)-oxirane

: 137103-59-4
1-(4-fluorophenyl)-1-[3-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / t-BuOK / dimethylformamide / 90 °C

2: 23 percent / Et₃N, Pd(PPh₃)2Cl₂ / dimethylformamide / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00095a009