Technology Process of [Bi-1-cyclohexen-1-yl]-3-one, 6-methyl-6-[4-(trimethylsilyl)-2-butenyl]-,
(Z)-
There total 5 articles about [Bi-1-cyclohexen-1-yl]-3-one, 6-methyl-6-[4-(trimethylsilyl)-2-butenyl]-,
(Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) LDA, HMPA / 1) hexane, THF, -78 deg C, 2) -78 deg C up to room temp.
2: 90 percent / H2 / 5percent Pd/BaSO4 / pyridine; methanol / 760 Torr / Ambient temperature
3: 1) tert-BuLi / 1) pentane, ether, -78 -> 0 deg C, 2 h, 2) ether, -70 -> 10 deg C, 3 h
4: 10percent aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; tert.-butyl lithium; lithium diisopropyl amide;
Pd-BaSO4;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1021/jo00012a034
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) LDA, HMPA / 1) hexane, THF, -78 deg C, 2) -78 deg C up to room temp.
2: 90 percent / H2 / 5percent Pd/BaSO4 / pyridine; methanol / 760 Torr / Ambient temperature
3: 1) tert-BuLi / 1) pentane, ether, -78 -> 0 deg C, 2 h, 2) ether, -70 -> 10 deg C, 3 h
4: 10percent aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; tert.-butyl lithium; lithium diisopropyl amide;
Pd-BaSO4;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1021/jo00012a034
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / H2 / 5percent Pd/BaSO4 / pyridine; methanol / 760 Torr / Ambient temperature
2: 1) tert-BuLi / 1) pentane, ether, -78 -> 0 deg C, 2 h, 2) ether, -70 -> 10 deg C, 3 h
3: 10percent aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature
With
hydrogenchloride; hydrogen; tert.-butyl lithium;
Pd-BaSO4;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1021/jo00012a034
