Cyclobenzaprine

Base Information

Chemical Name:Cyclobenzaprine
CAS No.:303-53-7
Molecular Formula:C20H21 N
Molecular Weight:275.393
Hs Code.:2921499090
European Community (EC) Number:206-145-8
UNII:69O5WQQ5TI
DSSTox Substance ID:DTXSID0046933
Nikkaji Number:J5.490I
Wikipedia:Cyclobenzaprine
Wikidata:Q5198674
NCI Thesaurus Code:C28947
RXCUI:21949
Pharos Ligand ID:V5Y6J1T72VV9
Metabolomics Workbench ID:43191
ChEMBL ID:CHEMBL669
Mol file:303-53-7.mol

Synonyms:cyclobenzaprine;cyclobenzaprine hydrochloride;Flexeril;Lisseril

Suppliers and Price of Cyclobenzaprine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cyclobenzaprine(1.0mg/mLinMethanol)
5x1ml
$ 105.00

American Custom Chemicals Corporation
CYCLOBENZAPRINE 95.00%
5MG
$ 497.28

AHH
Cyclobenzaprine 98%
0.05g
$ 410.00

Total 67 raw suppliers

Chemical Property of Cyclobenzaprine

Chemical Property:

Appearance/Colour:Solid
Vapor Pressure:7.65E-11mmHg at 25°C
Refractive Index:1.7500 (estimate)
Boiling Point:405.9 °C at 760 mmHg
PKA:pKa 8.47 (Uncertain)
Flash Point:177.8 °C
PSA：3.24000
Density:1.096 g/cm³
LogP:5.35580
XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:275.167399674
Heavy Atom Count:21
Complexity:365

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cyclobenzaprine(1.0mg/mLinMethanol) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31
Recent ClinicalTrials:Fixed-dose Combination of Etoricoxib + Cyclobenzaprine for Pain Relief After Third Molar Extraction in Brazil
Recent EU Clinical Trials:A SINGLE BLIND, SINGLE DOSE STUDY OF THE SEDATIVE EFFECTS OF THIOCOLCHICOSIDE, TIZANIDINE AND CYCLOBENZAPRINE IN HEALTHY MALE, HUMAN VOLUNTEERS
Description Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.
Uses Relaxant (muscle). It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.
Therapeutic Function Muscle relaxant

Technology Process of Cyclobenzaprine

There total 6 articles about Cyclobenzaprine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6682-26-4
cyclobenzaprine N-oxide

: 303-53-7
Cyclobenzaprine

Guidance literature:: With sodium tetrahydroborate; In water; at 50 - 60 ℃; chemoselective reaction;
DOI:10.1016/j.tetlet.2010.08.045

Reference yield:

: 18029-54-4
5-[3-(N,N-dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol

: 303-53-7
Cyclobenzaprine

Guidance literature:: With acetic anhydride; Heating;
DOI:10.1021/jo01048a057

Reference yield:

: 109-54-6
3-(Dimethylamino)propyl chloride

: 303-53-7
Cyclobenzaprine

Guidance literature:: Multi-step reaction with 2 steps

1: (i) Mg, (ii) /BRN= 743171/, THF

2: Ac₂O / Heating

With acetic anhydride;
DOI:10.1021/jo01048a057