1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:137496-70-9
Molecular Formula:C18H26N2O3
Molecular Weight:318.416
Hs Code.:
Mol file:137496-70-9.mol

Synonyms:(S)-2-(3,5-Dimethyl-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property:

PSA：58.64000
LogP:3.65230

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)-

There total 8 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(3,5-dimethylphenyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 108-69-0
3,5-dimethylaminoaniline

: 137496-70-9
(S)-tert-butyl 2-((3,5-dimethylphenyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/op500277s

Reference yield:

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 137496-70-9
(S)-tert-butyl 2-((3,5-dimethylphenyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec-BuLi; (-)-sparteine / diethyl ether / 1 h / -78 °C

1.2: CuCN*2LiCl / tetrahydrofuran; diethyl ether / 1 h / -78 - -60 °C

1.3: tetrahydrofuran; diethyl ether / 12 h / -60 - 25 °C

2.1: 49 percent / sodium metaperiodate; ruthenium trichloride hydrate / CCl₄; acetonitrile; H₂O / 0.75 h / 20 °C

3.1: dicyclohexylcarbodiimide; hydroxybenzotriazole / CH₂Cl₂ / 12 h / 20 °C

With ruthenium trichloride; sodium periodate; sec.-butyllithium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; (-)-sparteine; In tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/ja0156587