4-Thiazolecarboxylic acid, 2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-
• CAS No.: 137576-92-2
• Molecular Formula: C₁₄H₁₁N₃O₂S
• Molecular Weight: 285.326
• Mol file: 137576-92-2.mol

Synonyms:

Chemical Property of 4-Thiazolecarboxylic acid, 2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-

There total 3 articles about 4-Thiazolecarboxylic acid, 2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (18093-92-0) → 2-<4-(1-Phenyl-3-methylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-92-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / O,O-diethyldithiophosphoric acid, water / 3 h / 80 °C

2: 74 percent / ethanol / 0.75 h / Heating

3: 94 percent / 2 N aq. sodium hydroxide / ethanol / 0.5 h / Heating

With sodium hydroxide; water; O,O-Diethyl hydrogen phosphorodithioate; In ethanol;

DOI:10.1002/jhet.5570280625

Reference yield:

5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (5346-56-5) → 2-<4-(1-Phenyl-3-methylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-92-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / isopentylnitrite / tetrahydrofuran / Heating

2: 76 percent / O,O-diethyldithiophosphoric acid, water / 3 h / 80 °C

3: 74 percent / ethanol / 0.75 h / Heating

4: 94 percent / 2 N aq. sodium hydroxide / ethanol / 0.5 h / Heating

With sodium hydroxide; water; O,O-Diethyl hydrogen phosphorodithioate; isopentyl nitrite; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570280625

Reference yield:

1-Phenyl-3-methyl-4-pyrazolethiocarboxamide (137576-87-5) → 2-<4-(1-Phenyl-3-methylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / ethanol / 0.75 h / Heating

2: 94 percent / 2 N aq. sodium hydroxide / ethanol / 0.5 h / Heating

With sodium hydroxide; In ethanol;

DOI:10.1002/jhet.5570280625

upstream raw materials:

3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile

5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile

1-Phenyl-3-methyl-4-pyrazolethiocarboxamide